Gene

plk4

ID
ZDB-GENE-030619-14
Name
polo-like kinase 4 (Drosophila)
Symbol
plk4 Nomenclature History
Previous Names
  • stk18 (1)
  • wu:fi33g07
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in centriole assembly; cilium assembly; and developmental growth. Predicted to localize to several cellular components, including deuterosome; microtubule cytoskeleton; and nucleolus. Is expressed in brain; eye; nervous system; and pronephros. Used to study ciliopathy. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 2. Orthologous to human PLK4 (polo like kinase 4).
Genome Resources
Note
None
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from Martin et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With plk4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
microcephaly and chorioretinopathy 2 Alliance Microcephaly and chorioretinopathy, autosomal recessive, 2 616171
Associated With plk4 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000959 POLO box domain
Domain IPR033696 Plk4, C-terminal polo-box domain
Domain IPR033698 Plk4, second cryptic polo-box domain
Domain IPR033699 Plk4, first cryptic polo-box domain
Family IPR033700 Serine/threonine-protein kinase Plk4
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Plk4, C-terminal polo-box domain Plk4, first cryptic polo-box domain Plk4, second cryptic polo-box domain POLO box domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase Plk4 Tyrosine-protein kinase, active site
UniProtKB:Q7ZVS3 940
UniProtKB:F1RB74 941
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations