ZFIN ID: ZDB-GENE-030616-99
Gene Name: MHC class II beta chain-like
Gene Symbol: mhc2bl    Nomenclature History

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Previous Names: si:busm1-104n07.3, si:dz104n07.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to be involved in antigen processing and presentation and immune response. Predicted to localize to MHC class II protein complex and integral component of membrane. Human ortholog(s) of this gene implicated in asthma (multiple); hepatitis B; lung disease (multiple); and type 1 diabetes mellitus. Orthologous to human HLA-DPB1 (major histocompatibility complex, class II, DP beta 1); HLA-DQB2 (major histocompatibility complex, class II, DQ beta 2); and HLA-DRB5 (major histocompatibility complex, class II, DR beta 5).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000074510 (1)
Note: novel protein similar to MHC class II beta chain
GENE EXPRESSION
All Expression Data: 2 figures from Wu et al., 2018
Wild-type Stages, Structures: Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1580 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mhc2bl HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mhc2bl VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process antigen processing and presentation (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA si:busm1-104n07.3-001 (1) 769
    si:busm1-104n07.3-202 (1)    Ensembl 723
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mhc2bl No data available
    MARKER RELATIONSHIPS
    mhc2bl Contained in: [Fosmid] ZFOS-2070C2 (1)
    [PAC] BUSM1-104N07 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:AL591144 (1) 111434 nt
    Select Tool
    Polypeptide UniProtKB:F1QVI4 (1) 250 aa
    Sequence Information (all 6)
    ORTHOLOGY for mhc2bl ( Chr: 8 )
    CITATIONS (18)