ZFIN ID: ZDB-GENE-030616-72
Gene Name: ubiquitin-conjugating enzyme E2A (RAD6 homolog)
Gene Symbol: ube2a    Nomenclature History

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Previous Names: mp:zf637-2-000771, si:bz46j2.4, wu:fa01h11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have ubiquitin conjugating enzyme activity. Predicted to be involved in DNA repair; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to localize to HULC complex and nuclear chromatin. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Nascimento type. Orthologous to human UBE2A (ubiquitin conjugating enzyme E2 A).
Genome Resources: Alliance (1),  Gene:797853 (1),  Ensembl(GRCz11):ENSDARG00000098466 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:64109]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-ube2a N/A 2
MO2-ube2a N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ube2a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
syndromic X-linked intellectual disability Nascimento type Alliance Mental retardation, X-linked syndromic, Nascimento-type 300860
DISEASE ASSOCIATED WITH ube2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process DNA repair (more)
Cellular Component HULC complex (more)
Molecular Function ATP binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ube2a-202 (1)    Ensembl 679
ube2a-203 (1)    Ensembl 1685
ube2a-204 (1)    Ensembl 974
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ube2a No data available
MARKER RELATIONSHIPS
ube2a Contained in: [BAC] CH211-231B5 (1), RP71-46J2 (1)
ube2a Encodes: [EST] fa01h11 (1), zf637-2-000771 (1)
[cDNA] MGC:64109 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_201273 (1) 1626 nt
Genomic GenBank:BX247946 (1) 156559 nt
Select Tool
Polypeptide UniProtKB:Q789K9 (1) 152 aa
Sequence Information (all 17)
ORTHOLOGY for ube2a ( Chr: 14 )
CITATIONS (27)