ZFIN ID: ZDB-GENE-030616-609
Gene Name: protein phosphatase 1, catalytic subunit, beta isozyme
Gene Symbol: ppp1cb    Nomenclature History

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Previous Names: plb (1), ppp1cba (1), ik:tdsubc_2f2, si:zc214p16.4, wu:fa09h01, wu:fa11e06, xx:tdsubc_2f2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity. Involved in convergent extension involved in axis elongation and liver development. Predicted to localize to cytoplasm and nucleus. Is expressed in intestine and liver. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta).
Genome Resources: Alliance (1),  Gene:100003223 (1),  Ensembl(GRCz11):ENSDARG00000044153 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Blastula:256-cell (2.5h-2.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18605 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ppp1cb N/A 1
    MO2-ppp1cb N/A 1
    DISEASE ASSOCIATED WITH ppp1cb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Noonan syndrome-like disorder with loose anagen hair 2 Alliance Noonan syndrome-like disorder with loose anagen hair 2 617506
    DISEASE ASSOCIATED WITH ppp1cb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension involved in axis elongation (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein heterodimerization activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ppp1cb-201 (1)    Ensembl 2225
    ncRNA ppp1cb-002 (1)    Ensembl 629
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ppp1cb No data available
    MARKER RELATIONSHIPS
    ppp1cb Contained in: [BAC] CH211-214P16 (1), DKEY-98G12 (1) (order this)
    ppp1cb Encodes: [EST] fa09h01, fa11e06, tdsubc_2f2
    [cDNA] MGC:136442 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004527 (1) 2244 nt
    Genomic GenBank:AL929023 (1) 198736 nt
    Select Tool
    Polypeptide UniProtKB:F1QI59 (1) 327 aa
    Sequence Information (all 21)
    ORTHOLOGY for ppp1cb ( Chr: 17 )
    CITATIONS (30)