Gene

iars2

ID

ZDB-GENE-030616-608

Name

isoleucyl-tRNA synthetase 2, mitochondrial

Symbol

iars2 Nomenclature History

Previous Names

si:ch211-214p16.3 (1)
si:zc214p16.3

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation and mitochondrial translation. Predicted to localize to mitochondrion. Orthologous to human IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7148330 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With iars2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia	616007

Associated With iars2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site
Domain	IPR002300	Aminoacyl-tRNA synthetase, class Ia
Domain	IPR013155	Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
Domain	IPR033708	Isoleucyl tRNA synthetase type 1, anticodon-binding domain
Family	IPR002301	Isoleucine-tRNA ligase
Family	IPR023585	Isoleucine-tRNA ligase, type 1
Homologous_superfamily	IPR009008	Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Homologous_superfamily	IPR009080	Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold