Gene

plcb3

ID
ZDB-GENE-030616-594
Name
phospholipase C, beta 3 (phosphatidylinositol-specific)
Symbol
plcb3 Nomenclature History
Previous Names
  • she
  • si:ch211-188c22.1
  • si:zc188c22.1
  • wu:fl04b08
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have calmodulin binding activity and phosphatidylinositol phospholipase C activity. Involved in negative regulation of calcium ion import; negative regulation of vascular permeability; and skeletal system development. Is expressed in several structures, including epidermis; nervous system; otic vesicle; pharyngeal arch; and pronephric duct. Orthologous to human PLCB3 (phospholipase C beta 3).
Genome Resources
Note
None
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With plcb3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Spondylometaphyseal dysplasia with corneal dystrophy 618961
Associated With plcb3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR009535 Phospholipase C-beta, conserved site
Domain IPR000008 C2 domain
Domain IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
Domain IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
Domain IPR014815 Phospholipase C-beta, C-terminal domain
Domain IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
Domain IPR037862 PLC-beta, PH domain
Family IPR001192 Phosphoinositide phospholipase C family
Family IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR042531 Phospholipase C-beta, C-terminal domain superfamily
Domain Details Per Protein
Protein Length C2 domain C2 domain superfamily EF-hand domain pair Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta Phosphatidylinositol-specific phospholipase C, X domain Phosphoinositide phospholipase C family Phosphoinositide-specific phospholipase C, EF-hand-like domain Phospholipase C-beta, conserved site Phospholipase C-beta, C-terminal domain Phospholipase C-beta, C-terminal domain superfamily Phospholipase C, phosphatidylinositol-specific, Y domain PLC-beta, PH domain PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
UniProtKB:A0A0R4IVA6 1245
UniProtKB:A4IGD0 557
UniProtKB:Q7ZZ38 1244
UniProtKB:A2TJ25 1244
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations