ZFIN ID: ZDB-GENE-030616-572
Gene Name: scribble planar cell polarity protein
Gene Symbol: scrib    Nomenclature History

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Previous Names: scrb1 (1), landlocked, llk, scribble1 (1), si:ch211-12p8.1 (1), si:zc12p8.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity. Involved in several processes, including establishment of mitotic spindle orientation; morphogenesis of an epithelium; and nervous system development. Localizes to the membrane. Predicted to colocalize with the cell leading edge; ionotropic glutamate receptor complex; and synaptic membrane. Is expressed in brain and neural tube. Orthologous to human SCRIB (scribble planar cell polarity protein).
Genome Resources: Alliance (1),  Gene:368473 (1),  Ensembl(GRCz11):ENSDARG00000000861 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu1089]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026077Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029356Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • rw16 Point Mutation Unknown Missense
    rw468 Point Mutation Unknown Premature Stop
    sa12522 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12563 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12569 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21043 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21044 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34144 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34145 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-scrib
    1
    MO1-scrib N/A 9
    MO2-scrib N/A 2
    DISEASE ASSOCIATED WITH scrib HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH scrib VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension involved in gastrulation (more)
    Cellular Component membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 42)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001478 PDZ domain
    Repeat IPR001611 Leucine-rich repeat
    Repeat IPR003591 Leucine-rich repeat, typical subtype
    Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
    Homologous_superfamily IPR036034 PDZ superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA scrib-201 (1)    Ensembl 5175
    scrib-202 (1)    Ensembl 5600
    scrib-205 (1)    Ensembl 674
    scrib-209 (1)    Ensembl 7921
    scrib-210 (1)    Ensembl 8074
    ncRNA scrib-002 (1)    Ensembl 756
    scrib-003 (1)    Ensembl 736
    scrib-004 (1)    Ensembl 532
    scrib-005 (1)    Ensembl 213
    scrib-006 (1)    Ensembl 104
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM scrib No data available
    MARKER RELATIONSHIPS
    scrib Contained in: [BAC] CH211-12P8 (1), DKEY-86L18 (1) (order this)
    scrib Encodes: [EST] eu1089 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001007175 (1) 5175 bp
    Genomic GenBank:AL772146 (1) 187241 bp
    Select Tool
    Polypeptide UniProtKB:A0A1L1QZF0 (1) 1808 aa
    Sequence Information (all 56)
    ORTHOLOGY for scrib ( Chr: 7 )
    CITATIONS (49)