ZFIN ID: ZDB-GENE-030616-413
Gene Name: titin, tandem duplicate 1
Gene Symbol: ttn.1    Nomenclature History

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Previous Names: TTN1 (1), ttnb, ttnl, hm:zeh1256r, im:6911926, si:dZ167C3.1, si:dz249n21.1, wu:fc09a12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity and muscle alpha-actinin binding activity. Involved in myofibril assembly and skeletal muscle tissue development. Predicted to localize to M band; Z disc; and striated muscle thin filament. Is expressed in several structures, including cardiovascular system; floor plate; mesoderm; musculature system; and pectoral fin. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to human TTN (titin).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000000563 (2)
GENE EXPRESSION
All Expression Data: 74 figures from 6 publications
Directly Submitted Expression Data: 6 figures (7 images) from Thisse et al., 2004 [IMAGE:6911926]
  6 figures (9 images) from Thisse et al., 2004 [IMAGE:7137241]
  7 figures (13 images) from Thisse et al., 2004 [IMAGE:7152005]
  7 figures (19 images) from Thisse et al., 2005 [eu247]
  7 figures (15 images) from Thisse et al., 2004 [IMAGE:7148021]
  7 figures (17 images) from Thisse et al., 2004 [IMAGE:7158196]
  6 figures (17 images) from Thisse et al., 2004 [IMAGE:7155830]
  7 figures (16 images) from Thisse et al., 2004 [IMAGE:7158960]
  7 figures (18 images) from Thisse et al., 2004 [IMAGE:7159792]
  6 figures (13 images) from Thisse et al., 2004 [IMAGE:7163675]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu7916 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa529 Point Mutation Unknown Premature Stop ENU
    sa656 Point Mutation Unknown Premature Stop ENU
    sa2520 Point Mutation Unknown Premature Stop ENU
    sa2521 Point Mutation Unknown Premature Stop ENU
    sa7209 Point Mutation Unknown Premature Stop ENU
    sa7211 Point Mutation Unknown Premature Stop ENU
    sa8651 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
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    • sa8738 Point Mutation Unknown Premature Stop ENU
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    • sa8776 Point Mutation Unknown Premature Stop ENU
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    • sa8875 Point Mutation Unknown Premature Stop ENU
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    • sa9015 Point Mutation Unknown Premature Stop ENU
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    • sa10165 Point Mutation Unknown Premature Stop ENU
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    • sa10177 Point Mutation Unknown Splice Site ENU
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    • sa10376 Point Mutation Unknown Premature Stop ENU
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    • sa10627 Point Mutation Unknown Premature Stop ENU
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    • sa10628 Point Mutation Unknown Premature Stop ENU
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    • sa11847 Point Mutation Unknown Premature Stop ENU
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    • sa13738 Point Mutation Unknown Premature Stop ENU
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    • sa14252 Point Mutation Unknown Splice Site ENU
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    • sa14401 Point Mutation Unknown Premature Stop ENU
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    • sa14453 Point Mutation Unknown Premature Stop ENU
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    • sa14924 Point Mutation Unknown Premature Stop ENU
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    • sa15669 Point Mutation Unknown Premature Stop ENU
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    • sa15731 Point Mutation Unknown Premature Stop ENU
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    • sa16133 Point Mutation Unknown Premature Stop ENU
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    • sa16157 Point Mutation Unknown Splice Site ENU
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    • sa16201 Point Mutation Unknown Splice Site ENU
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    • sa16349 Point Mutation Unknown Premature Stop ENU
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    • sa16491 Point Mutation Unknown Premature Stop ENU
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    • sa16757 Point Mutation Unknown Splice Site ENU
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    • sa16841 Point Mutation Unknown Premature Stop ENU
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    • sa17186 Point Mutation Unknown Premature Stop ENU
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    • sa17611 Point Mutation Unknown Premature Stop ENU
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    • sa18121 Point Mutation Unknown Premature Stop ENU
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    • sa18130 Point Mutation Unknown Splice Site ENU
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    • sa18248 Point Mutation Unknown Premature Stop ENU
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    • sa18518 Point Mutation Unknown Premature Stop ENU
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    • sa18663 Point Mutation Unknown Premature Stop ENU
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    • sa21558 Point Mutation Unknown Premature Stop ENU
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    • sa21559 Point Mutation Unknown Premature Stop ENU
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    • sa21560 Point Mutation Unknown Premature Stop ENU
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    • sa21561 Point Mutation Unknown Premature Stop ENU
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    • sa21562 Point Mutation Unknown Premature Stop ENU
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    • sa21563 Point Mutation Unknown Premature Stop ENU
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    • sa21564 Point Mutation Unknown Splice Site ENU
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    • sa21565 Point Mutation Unknown Premature Stop ENU
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    • sa21566 Point Mutation Unknown Premature Stop ENU
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    • sa21567 Point Mutation Unknown Premature Stop ENU
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    • sa21568 Point Mutation Unknown Premature Stop ENU
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    • sa21569 Point Mutation Unknown Premature Stop ENU
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    • sa21570 Point Mutation Unknown Premature Stop ENU
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    • sa25435 Point Mutation Unknown Premature Stop ENU
    sa25436 Point Mutation Unknown Premature Stop ENU
    sa27455 Point Mutation Unknown Premature Stop ENU
    sa30923 Point Mutation Unknown Premature Stop ENU
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    • sa31742 Point Mutation Unknown Premature Stop ENU
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    • sa31743 Point Mutation Unknown Premature Stop ENU
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    • sa31744 Point Mutation Unknown Splice Site ENU
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    • sa34726 Point Mutation Unknown Premature Stop ENU
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    • sa34727 Point Mutation Unknown Premature Stop ENU
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    • sa34728 Point Mutation Unknown Splice Site ENU
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    • sa34729 Point Mutation Unknown Premature Stop ENU
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    • sa34730 Point Mutation Unknown Premature Stop ENU
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    • sa34731 Point Mutation Unknown Splice Site ENU
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    • sa34732 Point Mutation Unknown Splice Site ENU
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    • sa34733 Point Mutation Unknown Premature Stop ENU
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    • sa34734 Point Mutation Unknown Splice Site ENU
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    • sa34735 Point Mutation Unknown Splice Site ENU
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    • sa34736 Point Mutation Unknown Premature Stop ENU
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    • sa34737 Point Mutation Unknown Premature Stop ENU
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    • sa34738 Point Mutation Unknown Premature Stop ENU
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    • sa34739 Point Mutation Unknown Premature Stop ENU
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    • sa38756 Point Mutation Unknown Premature Stop ENU
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    • sa38757 Point Mutation Unknown Premature Stop ENU
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    • sa38758 Point Mutation Unknown Premature Stop ENU
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    • sa41509 Point Mutation Unknown Premature Stop ENU
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    • sa41510 Point Mutation Unknown Premature Stop ENU
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    • sa41511 Point Mutation Unknown Premature Stop ENU
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    • sa41512 Point Mutation Unknown Premature Stop ENU
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    • sa41513 Point Mutation Unknown Premature Stop ENU
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    • sa41514 Point Mutation Unknown Premature Stop ENU
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    • sa41515 Point Mutation Unknown Splice Site ENU
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    • sa41516 Point Mutation Unknown Premature Stop ENU
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    • sa41517 Point Mutation Unknown Premature Stop ENU
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    • sa41518 Point Mutation Unknown Premature Stop ENU
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    • sa41519 Point Mutation Unknown Splice Site ENU
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    • sa41520 Point Mutation Unknown Premature Stop ENU
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    • sa41521 Point Mutation Unknown Splice Site ENU
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    • sa41522 Point Mutation Unknown Premature Stop ENU
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    • sa41523 Point Mutation Unknown Premature Stop ENU
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    • sa44711 Point Mutation Unknown Unknown ENU
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    • sa44712 Point Mutation Unknown Unknown ENU
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    • sa45370 Point Mutation Unknown Premature Stop ENU
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    • sa45371 Point Mutation Unknown Premature Stop ENU
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    • sa45372 Point Mutation Unknown Premature Stop ENU
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    • xu066 Small Deletion Exon 5 Frameshift, Premature Stop TALEN
    xu067 Small Deletion Exon 177 Premature Stop TALEN
    xu069 Complex Unknown Unknown TALEN
    xu070 Complex Unknown Unknown TALEN
    xu071 Complex Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ttn.1 N/A 1
    MO2-ttn.1 N/A 3
    MO3-ttn.1 N/A 2
    MO4-ttn.1 N/A 1
    TALEN1-ttn.1 1
    TALEN2-ttn.1 1
    PHENOTYPE
    Data: 9 figures from 3 publications
    Observed in:
    DISEASE ASSOCIATED WITH ttn.1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive limb-girdle muscular dystrophy type 2J Alliance Muscular dystrophy, limb-girdle, autosomal recessive 10 608807
    dilated cardiomyopathy 1G Alliance Cardiomyopathy, dilated, 1G 604145
    hypertrophic cardiomyopathy 9 Alliance Cardiomyopathy, familial hypertrophic, 9 613765
    myofibrillar myopathy 9 Alliance Myopathy, myofibrillar, 9, with early respiratory failure 603689
    tibial muscular dystrophy Alliance Tibial muscular dystrophy, tardive 600334
    Salih myopathy 611705
    DISEASE ASSOCIATED WITH ttn.1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process myofibril assembly (more)
    Cellular Component membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ottdart00000004032 (1) 2267
    Select Tool
    ttn.1-002 (1) 67081
    Select Tool
    ttn.1-003 (1) 16776
    Select Tool
    ttn.1-201 (1)    Ensembl 88553
    Select Tool
    Browsers: Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ttn.1 No data available
    MARKER RELATIONSHIPS
    ttn.1 Contained in: [BAC] CH211-198B21 (1), DKEY-190I10 (1) (order this)
    [PAC] BUSM1-167C3 (1), BUSM1-249N21 (1)
    ttn.1 Encodes: [EST] eu247 (1), fc09a12 (1), fz71a10, IMAGE:6911926 (1), IMAGE:7137241 (1), IMAGE:7148021 (1), IMAGE:7152005 (1), IMAGE:7155830 (1), IMAGE:7158196 (1), IMAGE:7158960 (1), IMAGE:7159792 (1), IMAGE:7163675 (1), fc09b12 (1), fc52g09 (1), zeh1256r
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA WashUZ:wz12773 898 nt
    Genomic GenBank:DQ649453 (1) 441087 nt Blast at MegaBLAST
    Polypeptide UniProtKB:G1K2X0 (1) 29152 aa
    Select Tool
    Sequence Information (all 31)
    ORTHOLOGY for ttn.1 ( Chr: 9 )
    CITATIONS (39)
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