Gene

triob

ID
ZDB-GENE-030616-399
Name
trio Rho guanine nucleotide exchange factor b
Symbol
triob Nomenclature History
Previous Names
  • trio
  • si:dz230d15.1
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; guanyl-nucleotide exchange factor activity; and protein serine/threonine kinase activity. Predicted to be involved in axon guidance; central nervous system development; and protein phosphorylation. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability and autosomal dominant non-syndromic intellectual disability 44. Orthologous to human TRIO (trio Rho guanine nucleotide exchange factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2005
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With triob Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant non-syndromic intellectual disability 44 Alliance Intellectual developmental disorder, autosomal dominant 44, with microcephaly 617061
Intellectual developmental disorder, autosomal dominant 63, with macrocephaly 618825
Associated With triob Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000219 Dbl homology (DH) domain
Domain IPR000719 Protein kinase domain
Domain IPR001251 CRAL-TRIO lipid binding domain
Domain IPR001452 SH3 domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Family IPR028570 Rho GDP/GTP exchange factor Kalirin/TRIO
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Homologous_superfamily IPR036865 CRAL-TRIO lipid binding domain superfamily
Repeat IPR002017 Spectrin repeat
Repeat IPR018159 Spectrin/alpha-actinin
Domain Details Per Protein
Protein Length CRAL-TRIO lipid binding domain CRAL-TRIO lipid binding domain superfamily Dbl homology (DH) domain Dbl homology (DH) domain superfamily Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 PH-like domain superfamily Pleckstrin homology domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Rho GDP/GTP exchange factor Kalirin/TRIO Serine/threonine-protein kinase, active site SH3 domain SH3-like domain superfamily Spectrin/alpha-actinin Spectrin repeat
UniProtKB:F1QD90 2985
UniProtKB:Q801U0 757
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations