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Gene

stat4

ID
ZDB-GENE-030616-264
Name
signal transducer and activator of transcription 4
Symbol
stat4 Nomenclature History
Previous Names
  • si:by134g18.2
  • si:by51f19.1
  • si:dz182h3.3
  • si:dz199m19.1
  • si:dz73o4.2
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within vasculogenesis. Predicted to be located in cytoplasm and nucleus. Is expressed in anterior lateral plate mesoderm and pharyngeal arch. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; autoimmune disease (multiple); dermatomyositis; genital herpes; and systemic scleroderma (multiple). Orthologous to human STAT4 (signal transducer and activator of transcription 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Meng et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With stat4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Systemic lupus erythematosus, susceptibility to, 11} 612253
Associated With stat4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000980 SH2 domain
Domain IPR013799 STAT transcription factor, protein interaction
Domain IPR013800 STAT transcription factor, all-alpha domain
Domain IPR013801 STAT transcription factor, DNA-binding
Family IPR001217 Transcription factor STAT
Family IPR029839 Signal transducer and activator of transcription 4
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR012345 STAT transcription factor, DNA-binding, N-terminal
Homologous_superfamily IPR015988 STAT transcription factor, coiled coil
Homologous_superfamily IPR036535 STAT transcription factor, N-terminal domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length p53-like transcription factor, DNA-binding SH2 domain SH2 domain superfamily Signal transducer and activator of transcription 4 STAT transcription factor, all-alpha domain STAT transcription factor, coiled coil STAT transcription factor, DNA-binding STAT transcription factor, DNA-binding, N-terminal STAT transcription factor, N-terminal domain superfamily STAT transcription factor, protein interaction Transcription factor STAT
UniProtKB:Q7ZZ53 651
UniProtKB:Q7ZZ77 652
UniProtKB:Q8AW27 122
UniProtKB:Q8JFU7 553
UniProtKB:B0S790 731
UniProtKB:Q801X1 176
UniProtKB:Q8AW24 657
UniProtKB:A0A2R8S045 732
UniProtKB:A0A2R8Q947 741
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations