ZFIN ID: ZDB-GENE-030616-264
Gene Name: signal transducer and activator of transcription 4
Gene Symbol: stat4    Nomenclature History

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Previous Names: si:by134g18.2, si:by51f19.1, si:dz182h3.3, si:dz199m19.1, si:dz73o4.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in vasculogenesis. Predicted to localize to the cytosol and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; IgA glomerulonephritis; autoimmune hypersensitivity disease (multiple); genital herpes; and psoriatic arthritis. Is expressed in anterior lateral plate mesoderm and pharyngeal arch. Orthologous to human STAT4 (signal transducer and activator of transcription 4).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000028731 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21554 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25434 Point Mutation Unknown Premature Stop ENU
    sa34719 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf2070 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-stat4 1
    MO1-stat4 N/A 1
    DISEASE ASSOCIATED WITH stat4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Systemic lupus erythematosus, susceptibility to, 11} 612253
    DISEASE ASSOCIATED WITH stat4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process vasculogenesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function DNA binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000980 SH2 domain
    Family IPR001217 Transcription factor STAT
    Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
    Homologous_superfamily IPR012345 STAT transcription factor, DNA-binding, N-terminal
    Domain IPR013799 STAT transcription factor, protein interaction
    Domain IPR013800 STAT transcription factor, all-alpha domain
    Domain IPR013801 STAT transcription factor, DNA-binding
    Homologous_superfamily IPR015988 STAT transcription factor, coiled coil
    Family IPR029839 Signal transducer and activator of transcription 4
    Homologous_superfamily IPR036535 STAT transcription factor, N-terminal domain superfamily
    Homologous_superfamily IPR036860 SH2 domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ottdart00000001760 (1) 531
    ottdart00000001847 (1) 1655
    ottdart00000004046 (1) 2245
    stat4-202 (1)    Ensembl 2907
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM stat4 No data available
    MARKER RELATIONSHIPS
    stat4 Contained in: [BAC] CH211-196J1 (1), DKEY-115D18 (1) (order this), XX-113D7 (1), IZAB-51F19, XX-BY134G18
    [PAC] BUSM1-46I22 (1), BUSM1-73O4, BUSM1-182H3 (1), BUSM1-199M19
    stat4 Contains: [STS] chunp9518
    stat4 Encodes: [EST] eu693 (1), eu765 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA GenBank:AL924249 (1) 356 bp
    Genomic GenBank:BX649377 (1) 217898 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8Q947 (1) 741 aa
    Sequence Information (all 28)
    ORTHOLOGY for stat4 ( Chr: 9 )
    CITATIONS (29)