Gene
ivd
- ID
- ZDB-GENE-030616-262
- Name
- isovaleryl-CoA dehydrogenase
- Symbol
- ivd Nomenclature History
- Previous Names
-
- sb:cb425
- si:dz181p14.1
- wu:fb34d07
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have isovaleryl-CoA dehydrogenase activity. Predicted to be involved in leucine catabolic process and oxidation-reduction process. Is expressed in alar plate midbrain region; digestive system; immature eye; musculature system; and optic tectum. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and isovaleric acidemia. Orthologous to human IVD (isovaleryl-CoA dehydrogenase).
- Genome Resources
- Note
- None
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isovaleric acidemia | Alliance | Isovaleric acidemia | 243500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR006089 | Acyl-CoA dehydrogenase, conserved site |
| Domain | IPR006091 | Acyl-CoA oxidase/dehydrogenase, central domain |
| Domain | IPR009075 | Acyl-CoA dehydrogenase/oxidase C-terminal |
| Domain | IPR013786 | Acyl-CoA dehydrogenase/oxidase, N-terminal |
| Family | IPR034183 | Isovaleryl-CoA dehydrogenase |
| Homologous_superfamily | IPR009100 | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily |
| Homologous_superfamily | IPR036250 | Acyl-CoA dehydrogenase-like, C-terminal |
| Homologous_superfamily | IPR037069 | Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Acyl-CoA dehydrogenase, conserved site | Acyl-CoA dehydrogenase-like, C-terminal | Acyl-CoA dehydrogenase/oxidase C-terminal | Acyl-CoA dehydrogenase/oxidase, N-terminal | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily | Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily | Acyl-CoA oxidase/dehydrogenase, central domain | Isovaleryl-CoA dehydrogenase |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A286Y9D4
|
412 | ||||||||
|
UniProtKB:E7FGP9
|
413 | ||||||||
|
UniProtKB:E9QEY6
|
156 | ||||||||
|
UniProtKB:Q7ZTH9
|
418 | ||||||||
|
UniProtKB:Q8AW60
|
418 |
Interactions and Pathways
No data available
Plasmids
No data available