Gene

ivd

ID
ZDB-GENE-030616-262
Name
isovaleryl-CoA dehydrogenase
Symbol
ivd Nomenclature History
Previous Names
  • sb:cb425
  • si:dz181p14.1
  • wu:fb34d07
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have isovaleryl-CoA dehydrogenase activity. Predicted to be involved in leucine catabolic process and oxidation-reduction process. Is expressed in alar plate midbrain region; digestive system; immature eye; musculature system; and optic tectum. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and isovaleric acidemia. Orthologous to human IVD (isovaleryl-CoA dehydrogenase).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ivd Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
isovaleric acidemia Alliance Isovaleric acidemia 243500
Associated With ivd Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR006089 Acyl-CoA dehydrogenase, conserved site
Domain IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
Domain IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
Domain IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
Family IPR034183 Isovaleryl-CoA dehydrogenase
Homologous_superfamily IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
Homologous_superfamily IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
Homologous_superfamily IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
Domain Details Per Protein
Protein Length Acyl-CoA dehydrogenase, conserved site Acyl-CoA dehydrogenase-like, C-terminal Acyl-CoA dehydrogenase/oxidase C-terminal Acyl-CoA dehydrogenase/oxidase, N-terminal Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily Acyl-CoA oxidase/dehydrogenase, central domain Isovaleryl-CoA dehydrogenase
UniProtKB:A0A286Y9D4 412
UniProtKB:E7FGP9 413
UniProtKB:E9QEY6 156
UniProtKB:Q7ZTH9 418
UniProtKB:Q8AW60 418
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations