ZFIN Gene: ivd

ZFIN ID: ZDB-GENE-030616-262

ZFIN ID: ZDB-GENE-030616-262

Gene Name:

isovaleryl-CoA dehydrogenase

Gene Symbol:

ivd Nomenclature History

Previous Names:

sb:cb425, si:dz181p14.1, wu:fb34d07

Gene Type:

protein_coding_gene

Location:

Chr: 17 Mapping Details/Browsers

Description:

Predicted to have isovaleryl-CoA dehydrogenase activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to mitochondrion. Is expressed in alar plate midbrain region; digestive system; immature eye; musculature system; and optic tectum. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and isovaleric acidemia. Orthologous to human IVD (isovaleryl-CoA dehydrogenase).

Genome Resources:

Alliance (1), Gene:368775 (1), Ensembl(GRCz11):ENSDARG00000042853 (1)

GENE EXPRESSION
Directly Submitted Expression Data:	6 figures (16 images) from Thisse et al., 2001 [cb425]
	1 figure (1 image) from Thisse et al., 2004 [IMAGE:7136352]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
	alar plate midbrain region cloaca gut immature eye liver myotome optic tectum pectoral fin musculature solid lens vesicle unspecified
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa6485	Point Mutation	Unknown	Splice Site	ENU
sa23118	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE No data available

DISEASE ASSOCIATED WITH ivd HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
isovaleric acidemia	Alliance	Isovaleric acidemia	243500

DISEASE ASSOCIATED WITH ivd VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	oxidation-reduction process (more)
Molecular Function	acyl-CoA dehydrogenase activity (more)

GO Terms (all 6)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	ivd-201 (1)	2140	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	ivd-203 (1)	553	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ivd-003 (1)	752	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	ivd-004 (1)	575	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM ivd No data available

MARKER RELATIONSHIPS

ivd Contained in:	[BAC] CH211-210H14 (1) [PAC] BUSM1-181P14 (1)
ivd Contains:	[SNP] rs3728872 (1), rs3728873 (1), rs3728874 (1)
ivd Encodes:	[EST] cb425 (order this), fb34d07, IMAGE:7136352 (1) [cDNA] MGC:55688 (1), MGC:86783 (1), MGC:191695 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_201491 (1)	2119 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX649281 (1)	157279 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q7ZTH9 (1)	418 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 26)

ORTHOLOGY for ivd ( Chr: 17 )

CITATIONS (24)

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