Gene
ltk
- ID
- ZDB-GENE-030616-115
- Name
- leukocyte receptor tyrosine kinase
- Symbol
- ltk Nomenclature History
- Previous Names
-
- shd(l)
- si:dz107o16.1
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in iridophore differentiation; pigment cell development; and regulation of developmental pigmentation. Acts upstream of or within maintenance of cell number; melanocyte differentiation; and melanocyte migration. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Is expressed in several structures, including immature eye; iridoblast; neural crest; notochord; and pigment cell. Orthologous to several human genes including ALK (ALK receptor tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 36 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Neuroblastoma, susceptibility to, 3} | 613014 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site |
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000998 | MAM domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | MAM domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class II, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QVU0
|
1530 |
Interactions and Pathways
No data available
Plasmids
No data available