Gene

ltk

ID
ZDB-GENE-030616-115
Name
leukocyte receptor tyrosine kinase
Symbol
ltk Nomenclature History
Previous Names
  • shd(l)
  • si:dz107o16.1
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including iridophore differentiation; melanocyte migration; and pigment cell development. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in several structures, including immature eye; iridoblast; neural crest; notochord; and pigment cell. Orthologous to several human genes including LTK (leukocyte receptor tyrosine kinase).
Genome Resources
Note
None
Expression
All Expression Data
13 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
36 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ltk Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Neuroblastoma, susceptibility to, 3} 613014
Associated With ltk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR000998 MAM domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Family IPR026984 Leukocyte tyrosine kinase receptor
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily LDL receptor-like superfamily Leukocyte tyrosine kinase receptor Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat MAM domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class II, conserved site
UniProtKB:A0A2R8QED1 1500
UniProtKB:A0A0B5JW94 453
UniProtKB:F1QBU7 1504
UniProtKB:F1QVU0 1530
UniProtKB:B1PHI5 785
UniProtKB:A0A2R8QI76 1526
UniProtKB:Q8JFV0 1161
UniProtKB:B1PCZ3 1504
UniProtKB:B0LVZ8 1530
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations