Gene

ltk

ID

ZDB-GENE-030616-115

Name

leukocyte receptor tyrosine kinase

Symbol

ltk Nomenclature History

Previous Names

shd(l)
si:dz107o16.1

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including iridophore differentiation; melanocyte migration; and pigment cell development. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in several structures, including immature eye; iridoblast; neural crest; notochord; and pigment cell. Orthologous to several human genes including LTK (leukocyte receptor tyrosine kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 8 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 36 figures from 14 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ltk Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Neuroblastoma, susceptibility to, 3}	613014

Associated With ltk Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Conserved_site	IPR002011	Tyrosine-protein kinase, receptor class II, conserved site
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR000719	Protein kinase domain
Domain	IPR000998	MAM domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Family	IPR026984	Leukocyte tyrosine kinase receptor
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	LDL receptor-like superfamily	Leukocyte tyrosine kinase receptor	Low-density lipoprotein (LDL) receptor class A, conserved site	Low-density lipoprotein (LDL) receptor class A repeat	MAM domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, receptor class II, conserved site
UniProtKB:A0A0B5JW94 InterPro	453
UniProtKB:B1PHI5 InterPro	785
UniProtKB:F1QVU0 InterPro	1530
UniProtKB:F1QBU7 InterPro	1504
UniProtKB:A0A2R8QI76 InterPro	1526
UniProtKB:B1PCZ3 InterPro	1504
UniProtKB:B0LVZ8 InterPro	1530
UniProtKB:Q8JFV0 InterPro	1161
UniProtKB:A0A2R8QED1 InterPro	1500

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	ltk-201 (1) Ensembl	4652 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ltk-202 (1) Ensembl	4697 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations