ZFIN ID: ZDB-GENE-030529-3
Gene Name: alcohol dehydrogenase 8a
Gene Symbol: adh8a    Nomenclature History

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Previous Names: wu:fb62f02, zgc:77878

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits alcohol dehydrogenase (NAD+) activity. Involved in cellular response to xenobiotic stimulus and ethanol metabolic process. Predicted to localize to cytosol. Is expressed in female organism; intestine; liver; and ovary. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide).
Genome Resources: Alliance (1),  Gene:322482 (1),  Ensembl(GRCz11):ENSDARG00000091211 (1)
GENE EXPRESSION
All Expression Data: 5 figures from 5 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11223 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14886 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH adh8a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH adh8a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process alcohol metabolic process (more)
    Cellular Component cytosol (more)
    Molecular Function alcohol dehydrogenase (NAD+) activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA adh8a-201 (1)    Ensembl 1433
    ncRNA adh8a-002 (1)    Ensembl 578
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM adh8a No data available
    MARKER RELATIONSHIPS
    adh8a Contained in: [BAC] CH211-200O8 (1)
    adh8a Encodes: [EST] fb62f02 (1)
    [cDNA] MGC:77878 (1), MGC:111886 (1), MGC:154134 (1), MGC:192956 (1)
    adh8a Has Artifact: [cDNA] MGC:66178
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001001946 (1) 1464 nt
    Genomic GenBank:CR559943 (1) 147505 nt
    Select Tool
    Polypeptide UniProtKB:Q4QRI0 (1) 377 aa
    Sequence Information (all 23)
    ORTHOLOGY for adh8a ( Chr: 13 )
    CITATIONS (32)