ZFIN ID: ZDB-GENE-030523-1
Gene Name: troponin C type 1a (slow)
Gene Symbol: tnnc1a    Nomenclature History

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Previous Names: cTnC (1), tnnc1, sil, zgc:103465

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity; calcium ion binding activity; and calcium-dependent protein binding activity. Involved in cardiac muscle contraction; cardiac ventricle development; and response to activity. Predicted to localize to troponin complex. Is expressed in heart primordium; mesoderm; muscle; and pericardial region. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Z; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 13. Orthologous to human TNNC1 (troponin C1, slow skeletal and cardiac type).
Genome Resources: Alliance (1),  Gene:353247 (1),  Ensembl(GRCz11):ENSDARG00000011400 (1)
GENE EXPRESSION
All Expression Data: 11 figures from 8 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:103465]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
az5 Small Deletion Unknown Unknown CRISPR
az6 Indel Unknown Unknown CRISPR
m656 Unknown Unknown Unknown ENU
sa14726 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15521 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25192 Point Mutation Unknown Splice Site ENU
    sk25 Small Deletion Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tnnc1a 1
    MO1-tnnc1a N/A 1
    DISEASE ASSOCIATED WITH tnnc1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    dilated cardiomyopathy 1Z Alliance Cardiomyopathy, dilated, 1Z 611879
    hypertrophic cardiomyopathy 13 Alliance Cardiomyopathy, hypertrophic, 13 613243
    DISEASE ASSOCIATED WITH tnnc1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to activity (more)
    Cellular Component troponin complex (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tnnc1a-201 (1)    Ensembl 1089
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tnnc1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(TETRE:tnnc1a,EGFP) EGFPtnnc1a Danio rerio 1 2
    MARKER RELATIONSHIPS
    tnnc1a Contained in: [BAC] CH211-117K14 (1)
    tnnc1a Encodes: [cDNA] MGC:103465 (1), MGC:192052 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_181498 (1) 1769 nt
    Genomic GenBank:CR354596 (1) 172749 nt
    Select Tool
    Polypeptide UniProtKB:Q5XJB2 (1) 161 aa
    Sequence Information (all 15)
    ORTHOLOGY for tnnc1a ( Chr: 23 )
    CITATIONS (50)