ZFIN ID: ZDB-GENE-030521-13
Gene Name: cyclin-dependent kinase inhibitor 1Bb
Gene Symbol: cdkn1bb    Nomenclature History

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Previous Names: cdkn1b (1), kip1, fb64g10, im:7152670, p27, sb:cb611, wu:fb63g10, wu:fb64g10 (1), wu:fe18e03

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have chaperone binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Predicted to be involved in G1/S transition of mitotic cell cycle; negative regulation of cell cycle; and negative regulation of cell population proliferation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Is expressed in several structures, including axis; nervous system; pectoral fin; polster; and solid lens vesicle. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B).
Genome Resources: Alliance (1),  Gene:368329 (1),  Ensembl(GRCz11):ENSDARG00000054271 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-cdkn1bb N/A 3
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cdkn1bb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
multiple endocrine neoplasia type 4 Alliance Multiple endocrine neoplasia, type IV 610755
DISEASE ASSOCIATED WITH cdkn1bb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cell cycle arrest (more)
Cellular Component cytoplasm (more)
Molecular Function cyclin-dependent protein serine/threonine kinase inhibitor activity (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cdkn1bb-201 (1)    Ensembl 1921
ncRNA cdkn1bb-002 (1) 864
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cdkn1bb No data available
MARKER RELATIONSHIPS
cdkn1bb Contained in: [BAC] CH211-218P2 (1)
cdkn1bb Encodes: [EST] cb611 (1) (order this), fb63g10 (1), fb64g10, fe18e03 (1), IMAGE:7152670 (1)
[cDNA] MGC:65754 (1), MGC:77582 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_212792 (1) 1880 nt
Genomic GenBank:CR354430 (1) 197231 nt
Select Tool
Polypeptide UniProtKB:Q90YX4 (1) 179 aa
Sequence Information (all 23)
ORTHOLOGY for cdkn1bb ( Chr: 25 )
CITATIONS (80)