ZFIN ID: ZDB-GENE-030513-3
Gene Name: thyroid stimulating hormone subunit beta a
Gene Symbol: tshba    Nomenclature History

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Previous Name: tshb (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to contribute to hormone activity. Predicted to be involved in G protein-coupled receptor signaling pathway and hormone-mediated signaling pathway. Predicted to localize to cytoplasm and extracellular space. Is expressed in adenohypophyseal placode; head; and hypophysis. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 4 and hypothyroidism. Orthologous to human TSHB (thyroid stimulating hormone subunit beta).
Genome Resources: Alliance (1),  Gene:353223 (1),  Ensembl(GRCz11):ENSDARG00000033726 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH tshba HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital nongoitrous hypothyroidism 4 Alliance Hypothyroidism, congenital, nongoitrous 4 275100
DISEASE ASSOCIATED WITH tshba VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process G protein-coupled receptor signaling pathway (more)
Cellular Component extracellular region (more)
Molecular Function hormone activity (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tshba-202 (1)    Ensembl 826
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tshba
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-2.5tshb:EGFP) tshba EGFP Danio rerio 1 3
Tg(tshb:EGFP) tshba EGFP Danio rerio 1 5
MARKER RELATIONSHIPS
tshba Contained in: [BAC] CH211-105J21 (1)
tshba Encodes: [cDNA] MGC:193962 (1), MGC:193992 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_181494 (1) 816 nt
Genomic GenBank:BX005150 (1) 167946 nt
Select Tool
Polypeptide UniProtKB:B3DJU0 (1) 148 aa
Sequence Information (all 19)
ORTHOLOGY for tshba ( Chr: 6 )
CITATIONS (146)