ZFIN ID: ZDB-GENE-030502-3
Gene Name: melanocortin 3 receptor
Gene Symbol: mc3r    Nomenclature History

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Previous Name: zgc:194235

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have melanocyte-stimulating hormone receptor activity and peptide hormone binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to localize to cytoplasm and plasma membrane. Is expressed in brain and epiphysis. Human ortholog(s) of this gene implicated in obesity. Orthologous to human MC3R (melanocortin 3 receptor).
Genome Resources: Alliance (1),  Gene:353153 (1),  Ensembl(GRCz11):ENSDARG00000021369 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa398 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mc3r
    1
    MO1-mc3r N/A 1
    PHENOTYPE
    Data: Fig. 7 from Renquist et al., 2013
    Observed in:
    DISEASE ASSOCIATED WITH mc3r HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Obesity, severe, susceptibility to, BMIQ9} 602025
    DISEASE ASSOCIATED WITH mc3r VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process G protein-coupled receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function G protein-coupled receptor activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mc3r-201 (1)    Ensembl 1050
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mc3r No data available
    MARKER RELATIONSHIPS
    mc3r Contained in: [BAC] DKEY-109A10 (1) (order this)
    mc3r Encodes: [cDNA] MGC:194235 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_180972 (1) 984 nt
    Genomic GenBank:CU639397 (1) 83876 nt
    Select Tool
    Polypeptide UniProtKB:B3DHF6 (1) 327 aa
    Sequence Information (all 12)
    ORTHOLOGY for mc3r ( Chr: 8 )
    CITATIONS (36)