ZFIN ID: ZDB-GENE-030323-1
Gene Name: fibroblast growth factor receptor 2
Gene Symbol: fgfr2
Sequence Ontology ID : SO:0000704

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Previous Names: fc56c05, wu:fc56c05

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(Including Attributions)
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 39 figures from 23 publications
Directly Submitted Expression Data: 7 figures (23 images) from Thisse et al., 2008 [cssl:d0138]
Wild-type Stages, Structures: Gastrula:90%-epiboly (9.0h-10.0h) to Adult (90d-730d, breeding adult)
  anatomical structure, anterior neural plate, basal plate midbrain region, brain (all 80) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu2897 Point Mutation Unknown Unknown ENU
hu2987 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la012423Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018672Tg Transgenic Insertion Unknown Unknown DNA
    sa10729 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24945 Point Mutation Unknown Splice Site ENU
    sa30975 Point Mutation Unknown Premature Stop ENU
    sa35586 Point Mutation Unknown Premature Stop ENU
    sa42295 Point Mutation Unknown Premature Stop ENU
    sa42296 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: MO1-fgfr2 (1), MO2-fgfr2 (1), MO3-fgfr2 (1), MO4-fgfr2 (1), MO5-fgfr2 (1) (all 8) expand
    PHENOTYPE
    Data: 10 figures from 3 publications
    Observed in: cell proliferation in midbrain, determination of liver left/right asymmetry, determination of pancreatic left/right asymmetry, enteroendocrine cell (all 13) expand
    DISEASE ASSOCIATED WITH fgfr2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    acrocephalosyndactylia Apert syndrome 101200
    Antley-Bixler syndrome Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis 207410
    Beare-Stevenson cutis gyrata syndrome Beare-Stevenson cutis gyrata syndrome 123790
    Crouzon syndrome Crouzon syndrome 123500
    LADD syndrome LADD syndrome 149730
    Pfeiffer syndrome Craniofacial-skeletal-dermatologic dysplasia 101600
    Pfeiffer syndrome 101600
    pre-eclampsia Bent bone dysplasia syndrome 614592
    Saethre-Chotzen syndrome Saethre-Chotzen syndrome 101400
    stomach cancer Gastric cancer, somatic 613659
    Scaphocephaly and Axenfeld-Rieger anomaly
    Jackson-Weiss syndrome 123150
    Scaphocephaly, maxillary retrusion, and mental retardation 609579
    Craniosynostosis, nonspecific
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell proliferation in midbrain (more)
    Cellular Component Golgi apparatus (more)
    Molecular Function fibroblast growth factor binding (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR016248 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR028175 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA fgfr2-001 (1) 4750
    mRNA fgfr2-002 (1) 3076
    fgfr2-003 (1) 4885
    fgfr2-004 (1) 2448
    fgfr2-005 (1) 3224
    ncRNA fgfr2-006 (1) 542
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM fgfr2 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    fgfr2Contained in: [BAC] CH73-216N19 (1) (order this), CH73-304G8 (1) (order this)
    [Fosmid] CH1073-215E5 (1) (order this)
    fgfr2Encodes: [EST] cssl:d0138 (1) (order this), fc56c05
    [cDNA] MGC:158199 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001243004 (1) 5326bp
    Genomic GenBank:CU862017 (1) 96381bp
    Select Tool
    Polypeptide UniProtKB:F8W2E2 (1) 840aa
    Sequence Clusters UniGene:116399 (1)
    Sequence Information (all 45)
    OTHER fgfr2 GENE PAGES
  • Gene:352940 (1)
  • VEGA:OTTDARG00000033929 (1)
  • Ensembl(GRCz10):ENSDARG00000058115 (1)
  • ORTHOLOGY for fgfr2 (Chr: 13)
    CITATIONS (75)