ZFIN ID: ZDB-GENE-030323-1
Gene Name: fibroblast growth factor receptor 2
Gene Symbol: fgfr2    Nomenclature History

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Previous Names: fc56c05, wu:fc56c05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits fibroblast growth factor binding activity. Involved in several processes, including cell proliferation in midbrain; determination of left/right symmetry; and regulation of hematopoietic stem cell differentiation. Predicted to localize to the integral component of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in several diseases, including Antley-Bixler syndrome; Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; reproductive organ cancer (multiple); and synostosis (multiple). Is expressed in several structures, including anterior neural rod; digestive system; mesoderm; nervous system; and trunk vasculature. Orthologous to human FGFR2 (fibroblast growth factor receptor 2).
Genome Resources: Alliance (1),  Gene:352940 (1),  Ensembl(GRCz11):ENSDARG00000058115 (2)
GENE EXPRESSION
All Expression Data: 43 figures from 26 publications
Directly Submitted Expression Data: 7 figures (23 images) from Thisse et al., 2008 [cssl:d0138]
Wild-type Stages, Structures: Gastrula:90%-epiboly (9.0h-10.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu2897 Point Mutation Unknown Unknown ENU
hu2987 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la012423Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018672Tg Transgenic Insertion Unknown Unknown DNA
    sa10729 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24945 Point Mutation Unknown Splice Site ENU
    sa30975 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35586 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42295 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42296 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-fgfr2
    2
    CRISPR2-fgfr2
    1
    MO1-fgfr2 N/A 3
    MO2-fgfr2 N/A 1
    MO3-fgfr2 N/A 1
    MO4-fgfr2 N/A 2
    MO5-fgfr2 N/A 2
    MO6-fgfr2 N/A 1
    MO7-fgfr2 N/A 1
    MO8-fgfr2 N/A 1
    DISEASE ASSOCIATED WITH fgfr2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acrocephalosyndactylia Alliance Apert syndrome 101200
    Antley-Bixler syndrome Alliance Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis 207410
    Beare-Stevenson cutis gyrata syndrome Alliance Beare-Stevenson cutis gyrata syndrome 123790
    Crouzon syndrome Alliance Crouzon syndrome 123500
    Jackson-Weiss syndrome Alliance Jackson-Weiss syndrome 123150
    LADD syndrome Alliance LADD syndrome 149730
    Pfeiffer syndrome Alliance Craniofacial-skeletal-dermatologic dysplasia 101600
    Pfeiffer syndrome 101600
    pre-eclampsia Alliance Bent bone dysplasia syndrome 614592
    Saethre-Chotzen syndrome Alliance Saethre-Chotzen syndrome 101400
    stomach cancer Alliance Gastric cancer, somatic 613659
    Craniosynostosis, nonspecific
    Scaphocephaly and Axenfeld-Rieger anomaly
    Scaphocephaly, maxillary retrusion, and mental retardation 609579
    DISEASE ASSOCIATED WITH fgfr2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell proliferation in midbrain (more)
    Cellular Component cytoplasmic vesicle (more)
    Molecular Function fibroblast growth factor binding (more)
    GO Terms (all 34)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Domain IPR003598 Immunoglobulin subtype 2
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Domain IPR013098 Immunoglobulin I-set
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Family IPR016248 Fibroblast growth factor receptor family
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    Domain IPR041159 Fibroblast growth factor receptor, transmembrane domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fgfr2-202 (1)    Ensembl 4885
    fgfr2-204 (1)    Ensembl 3076
    fgfr2-205 (1)    Ensembl 2448
    fgfr2-206 (1)    Ensembl 3224
    ncRNA fgfr2-006 (1)    Ensembl 542
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fgfr2 No data available
    MARKER RELATIONSHIPS
    fgfr2 Contained in: [BAC] CH73-216N19 (1), CH73-304G8 (1)
    [Fosmid] CH1073-215E5 (1)
    fgfr2 Encodes: [EST] cssl:d0138 (1), fc56c05
    [cDNA] MGC:158199 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001243004 (1) 5326 bp
    Genomic GenBank:CU862017 (1) 96381 bp
    Select Tool
    Polypeptide UniProtKB:F8W2E2 (1) 840 aa
    Sequence Information (all 43)
    ORTHOLOGY for fgfr2 ( Chr: 13 )
    CITATIONS (97)