Gene

fgfr2

ID
ZDB-GENE-030323-1
Name
fibroblast growth factor receptor 2
Symbol
fgfr2 Nomenclature History
Previous Names
  • fgfr2b (1)
  • fgfr2c (1)
  • fc56c05
  • wu:fc56c05
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits fibroblast growth factor binding activity. Involved in several processes, including cell proliferation in midbrain; determination of left/right symmetry; and regulation of hematopoietic stem cell differentiation. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in several structures, including anterior neural rod; digestive system; mesoderm; nervous system; and trunk vasculature. Human ortholog(s) of this gene implicated in several diseases, including Antley-Bixler syndrome; Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; reproductive organ cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2).
Genome Resources
Note
None
Expression
All Expression Data
45 figures from 28 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fgfr2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acrocephalosyndactylia Alliance Apert syndrome 101200
Antley-Bixler syndrome Alliance Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis 207410
Beare-Stevenson cutis gyrata syndrome Alliance Beare-Stevenson cutis gyrata syndrome 123790
Crouzon syndrome Alliance Crouzon syndrome 123500
Jackson-Weiss syndrome Alliance Jackson-Weiss syndrome 123150
LADD syndrome Alliance LADD syndrome 149730
Pfeiffer syndrome Alliance Craniofacial-skeletal-dermatologic dysplasia 101600
Pfeiffer syndrome Alliance Pfeiffer syndrome 101600
pre-eclampsia Alliance Bent bone dysplasia syndrome 614592
Saethre-Chotzen syndrome Alliance Saethre-Chotzen syndrome 101400
stomach cancer Alliance Gastric cancer, somatic 613659
Craniosynostosis, nonspecific
Scaphocephaly and Axenfeld-Rieger anomaly
Scaphocephaly, maxillary retrusion, and mental retardation 609579
Associated With fgfr2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR041159 Fibroblast growth factor receptor, transmembrane domain
Family IPR016248 Fibroblast growth factor receptor family
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Fibroblast growth factor receptor family Fibroblast growth factor receptor, transmembrane domain Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain
UniProtKB:Q8JG38 817
UniProtKB:Q805B9 815
UniProtKB:A4JYI8 751
UniProtKB:F1RBT3 815
UniProtKB:A4QN31 728
UniProtKB:Q8AYP3 815
UniProtKB:F8W376 838
UniProtKB:F1RBS5 815
UniProtKB:F8W2E2 840
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations