ZFIN ID: ZDB-GENE-030318-1
Gene Name: chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)
Gene Symbol: cxcl12a    Nomenclature History

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Previous Names: cxcl12 (1), SDF-1 (1), sdf-1a (1), sdf1a (1), unm t30516, unm_t30516, wu:fa55e10 (1), wu:fc16h12 (1), wu:fj84c02 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits chemoattractant activity. Involved in several processes, including fin regeneration; nervous system development; and regulation of cell migration. Predicted to localize to extracellular region. Is expressed in several structures, including brain; mesoderm; myoseptum; neural rod; and sensory system. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12).
Genome Resources: Alliance (1),  Gene:352944 (1),  Ensembl(GRCz11):ENSDARG00000037116 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12849 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35516 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t30516 Point Mutation Unknown Premature Stop ENU
    tsu4cd Small Deletion Exon 2 Unknown CRISPR
    u766 Unknown Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cxcl12a
    1
    CRISPR2-cxcl12a 1
    MO1-cxcl12a N/A 2
    MO2-cxcl12a N/A 13
    MO3-cxcl12a N/A 12
    MO4-cxcl12a N/A 21
    MO5-cxcl12a N/A 1
    MO6-cxcl12a N/A 3
    MO7-cxcl12a N/A 2
    MO8-cxcl12a N/A 1
    MO9-cxcl12a N/A 2
    DISEASE ASSOCIATED WITH cxcl12a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {AIDS, resistance to} 609423
    DISEASE ASSOCIATED WITH cxcl12a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fin regeneration (more)
    Cellular Component extracellular region (more)
    Molecular Function chemoattractant activity (more)
    GO Terms (all 33)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cxcl12a-201 (1)    Ensembl 3041
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cxcl12a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(cxcl12a:DsRed2) cxcl12a DsRed2 Danio rerio 2 8
    Tg(hsp70l:cxcl12a) hsp70l cxcl12a Danio rerio 1 8
    Tg(hsp70l:cxcl12a,EGFP) hsp70l cxcl12aEGFP Danio rerio 1 2
    Tg(hsp70l:cxcl12a-mCherry-Xla.Hbg1) hsp70l cxcl12amCherry Danio rerioXenopus laevis 1 3
    Tg(hsp70l:cxcl12a-UTR-nanos3,EGFP-UTR-nanos3) hsp70l cxcl12aEGFPnanos3 Danio rerio 1 2
    Tg2(hsp70l:cxcl12a) hsp70l cxcl12a Danio rerio 1 2
    TgBAC(cxcl12a:Cerulean) cxcl12a Cerulean Danio rerio 1 1
    TgBAC(cxcl12a:cxcl12a-3xFLAG-4xHA,cryaa:DsRed) cryaacxcl12a cxcl12aDsRedFLAGHA Danio rerio 1 1
    TgBAC(cxcl12a:cxcl12a-EGFP,cryaa:DsRed) cryaacxcl12a cxcl12aDsRedEGFP Danio rerio 2 4
    MARKER RELATIONSHIPS
    cxcl12a Contained in: [BAC] DKEY-228B19 (1) (order this)
    cxcl12a Contains: [STS] chunp30664
    cxcl12a Encodes: [EST] fa55e10, fc16h12
    [cDNA] MGC:123091 (1)
    cxcl12a Is Hybridized by: [EST] fj84c02
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_178307 (1) 1521 nt
    Genomic GenBank:CR762493 (1) 168643 nt
    Select Tool
    Polypeptide UniProtKB:Q8AV10 (1) 99 aa
    Sequence Information (all 21)
    ORTHOLOGY for cxcl12a ( Chr: 13 )
    CITATIONS (171)