ZFIN ID: ZDB-GENE-030314-1
Gene Name: cholinergic receptor, muscarinic 2a
Gene Symbol: chrm2a    Nomenclature History

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Previous Name: chrm2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have G protein-coupled acetylcholine receptor activity and G protein-coupled serotonin receptor activity. Involved in negative regulation of heart rate. Predicted to localize to dendrite; integral component of plasma membrane; and synapse. Is expressed in several structures, including cardiovascular system; central nervous system; digestive system; head; and neural tube. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; asthma; bipolar disorder; heroin dependence; and major depressive disorder. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2).
Genome Resources: Alliance (1),  Gene:352938 (1),  Ensembl(GRCz11):ENSDARG00000098612 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11876 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-chrm2a N/A 2
    MO2-chrm2a N/A 1
    DISEASE ASSOCIATED WITH chrm2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH chrm2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of heart rate (more)
    Cellular Component cell junction (more)
    Molecular Function G protein-coupled acetylcholine receptor activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA chrm2a-201 (1)    Ensembl 1754
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chrm2a No data available
    MARKER RELATIONSHIPS
    chrm2a Contained in: [BAC] CH211-117I20 (1), CH211-209O4 (1), DKEY-242N8 (1) (order this)
    chrm2a Encodes: [EST] eu64 (1)
    [cDNA] MGC:195344 (1), MGC:195354 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_178301 (1) 1488 nt
    Genomic GenBank:CR356243 (1) 216472 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B3DKN8 (1) 495 aa
    Sequence Information (all 27)
    ORTHOLOGY for chrm2a ( Chr: 4 )
    CITATIONS (30)