Gene

chrm2a

ID
ZDB-GENE-030314-1
Name
cholinergic receptor, muscarinic 2a
Symbol
chrm2a Nomenclature History
Previous Names
  • chrm2
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have G protein-coupled acetylcholine receptor activity and G protein-coupled serotonin receptor activity. Involved in negative regulation of heart rate. Predicted to localize to dendrite; integral component of plasma membrane; and synapse. Is expressed in several structures, including cardiovascular system; central nervous system; digestive system; head; and neural tube. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; asthma; bipolar disorder; heroin dependence; and major depressive disorder. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2).
Genome Resources
Note
None
Expression
All Expression Data
11 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With chrm2a Human Ortholog
No data available
Associated With chrm2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000995 Muscarinic acetylcholine receptor family
Family IPR001065 Muscarinic acetylcholine receptor M2
Domain Details Per Protein
Protein Length GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like Muscarinic acetylcholine receptor family Muscarinic acetylcholine receptor M2
UniProtKB:Q502R6 389
UniProtKB:B3DKN8 495
UniProtKB:Q801M4 495
UniProtKB:Q66IC1 313
UniProtKB:Q1RM28 406
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations