ZFIN ID: ZDB-GENE-030219-83
Gene Name: methionyl-tRNA synthetase 1
Gene Symbol: mars1    Nomenclature History

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Previous Names: mars, id:ibd5106

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and methionine-tRNA ligase activity. Predicted to be involved in tRNA aminoacylation for protein translation. Predicted to localize to cytosol. Is expressed in immature eye; midbrain; and somite. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2U. Orthologous to human MARS1 (methionyl-tRNA synthetase 1).
Genome Resources: Alliance (1),  Gene:338183 (1),  Ensembl(GRCz11):ENSDARG00000034396 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (2 images) from Kudoh et al., 2001 [ibd5106]
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi4134Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7590 Point Mutation Unknown Missense ENU
    sa16933 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33988 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40814 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40815 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mars1 N/A 1
    DISEASE ASSOCIATED WITH mars1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease axonal type 2U Alliance Charcot-Marie-Tooth disease, axonal, type 2U 616280
    Interstitial lung and liver disease 615486
    DISEASE ASSOCIATED WITH mars1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process methionyl-tRNA aminoacylation (more)
    Cellular Component cytosol (more)
    Molecular Function aminoacyl-tRNA ligase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mars-201 (1)    Ensembl 3147
    mars-202 (1)    Ensembl 3165
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mars1 No data available
    MARKER RELATIONSHIPS
    mars1 Contained in: [BAC] CH211-125M22 (1)
    mars1 Encodes: [EST] ibd5106
    [cDNA] MGC:66122 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200076 (1) 3191 nt
    Genomic GenBank:BX950854 (1) 171896 nt
    Select Tool
    Polypeptide UniProtKB:F1QFL1 (1) 951 aa
    Sequence Information (all 19)
    ORTHOLOGY for mars1 ( Chr: 6 )
    CITATIONS (33)