Gene

mars1

ID
ZDB-GENE-030219-83
Name
methionyl-tRNA synthetase 1
Symbol
mars1 Nomenclature History
Previous Names
  • mars
  • id:ibd5106
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and methionine-tRNA ligase activity. Predicted to be involved in tRNA aminoacylation for protein translation. Predicted to localize to cytosol. Is expressed in immature eye; midbrain; and somite. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2U. Orthologous to human MARS1 (methionyl-tRNA synthetase 1).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Kudoh et al., 2001
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mars1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease axonal type 2U Alliance Charcot-Marie-Tooth disease, axonal, type 2U 616280
Interstitial lung and liver disease 615486
Associated With mars1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
Domain IPR000738 WHEP-TRS domain
Domain IPR004045 Glutathione S-transferase, N-terminal
Domain IPR010987 Glutathione S-transferase, C-terminal-like
Domain IPR015413 Methionyl/Leucyl tRNA synthetase
Domain IPR033911 Methioninyl-tRNA synthetase core domain
Domain IPR041598 Methionine--tRNA ligase, N-terminal
Domain IPR041872 Methionyl-tRNA synthetase, anticodon-binding domain
Family IPR014758 Methionyl-tRNA synthetase
Family IPR023458 Methionine-tRNA ligase, type 1
Homologous_superfamily IPR009068 S15/NS1, RNA-binding
Homologous_superfamily IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily IPR029038 Methionyl-tRNA synthetase, Zn-domain
Homologous_superfamily IPR036249 Thioredoxin-like superfamily
Homologous_superfamily IPR036282 Glutathione S-transferase, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class Ia, anticodon-binding Aminoacyl-tRNA synthetase, class I, conserved site Glutathione S-transferase, C-terminal domain superfamily Glutathione S-transferase, C-terminal-like Glutathione S-transferase, N-terminal Methionine--tRNA ligase, N-terminal Methionine-tRNA ligase, type 1 Methioninyl-tRNA synthetase core domain Methionyl/Leucyl tRNA synthetase Methionyl-tRNA synthetase Methionyl-tRNA synthetase, anticodon-binding domain Methionyl-tRNA synthetase, Zn-domain Rossmann-like alpha/beta/alpha sandwich fold S15/NS1, RNA-binding Thioredoxin-like superfamily WHEP-TRS domain
UniProtKB:Q6TEM5 922
UniProtKB:Q6DRB3 913
UniProtKB:Q6PFQ4 913
UniProtKB:F1QFL1 951
UniProtKB:F1QVW1 942
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations