ZFIN Gene: bmper

ZFIN ID: ZDB-GENE-030219-146

ZFIN ID: ZDB-GENE-030219-146

Gene Name:

BMP binding endothelial regulator

Gene Symbol:

bmper

Sequence Ontology ID :

SO:0001217

Previous Names:

Crossveinless 2 (1), cv2 (1), cvl2 (1), id:ibd5071 (1)

Location:

Chr: 16 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Exhibits extracellular matrix binding activity. Involved in several processes, including animal organ development; regulation of BMP signaling pathway; and regulation of angiogenesis. Localizes to ...

GENE EXPRESSION
All Expression Data:	20 figures from 11 publications
Directly Submitted Expression Data:	3 figures (6 images) from Kudoh et al., 2001 [ibd5071]
Wild-type Stages, Structures:	Blastula:Dome (4.33h-4.66h) to Larval:Days 21-29 (21d-30d, 7.8mm, 10 teeth)
	anterior lateral mesoderm aortic arch blastoderm branchiostegal ray branchiostegal ray 3 ceratohyal bone ceratohyal cartilage cleithrum dentary diencephalon ectoderm endoderm entopterygoid epibranchial placode epiphysis extraocular musculature gut head immature eye intermediate cell mass of mesoderm lateral dorsal aorta lateral mesoderm lens maxilla midline column neural crest neurocranial trabecula opercle otic placode otic vesicle parachordal cartilage parasphenoid paraxial mesoderm pectoral fin pectoral fin cartilage pharyngeal arch pharyngeal arch 2 skeleton pharyngeal endoderm pharyngeal pouch posterior lateral line ganglion prechordal plate presumptive ectoderm pronephric duct opening solid lens vesicle tail bud unspecified ventral mesoderm ventral wall of dorsal aorta whole organism ventral side whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa108	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa30999	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa36040	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

PHENOTYPE

Data:	9 figures from 5 publications
Observed in:	blood cell blood circulation caudal artery caudal vein caudal vein plexus dorsal longitudinal anastomotic vessel hemopoiesis inner ear intermediate cell mass of mesoderm intersegmental vein intersegmental vessel otolith post-vent region post-vent vasculature somite sprouting angiogenesis whole organism

DISEASE ASSOCIATED WITH bmper HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
	Diaphanospondylodysostosis	608022

DISEASE ASSOCIATED WITH bmper VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	dorsal/ventral pattern formation (more)
Cellular Component	extracellular matrix (more)
Molecular Function	extracellular matrix binding (more)

GO Terms (all 11)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR001007 (1) InterPro:IPR001846 (1) InterPro:IPR002919 (1) InterPro:IPR014853 (1) InterPro:IPR036084 (1)	PROSITE:PS01208 (1) PROSITE:PS50184 (1) PROSITE:PS51233 (1)	Pfam:PF00093 (1) Pfam:PF00094 (1) Pfam:PF01826 (1) Pfam:PF08742 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	bmper-203 (1)	2181	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION No description available

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM bmper No data available

MARKER RELATIONSHIPS

bmper Contained in:	[Fosmid] CH1073-402O14 (1) (order this)
bmper Encodes:	[EST] ibd5071 (order this) [cDNA] MGC:162070 (1) (order this), MGC:193655 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001020487 (1)	2831 bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU683894 (1)	36404 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A6H8K2 (1)	668 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:38460 (1)

Sequence Information (all 30)

OTHER bmper GENE PAGES

Alliance (1)

Gene:338246 (1)

VEGA:OTTDARG00000034289 (1)

Ensembl(GRCz11):ENSDARG00000101980 (1)

ORTHOLOGY for bmper ( Chr: 16 )

CITATIONS (36)

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