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Gene

rps6ka3a

ID
ZDB-GENE-030219-119
Name
ribosomal protein S6 kinase a, polypeptide 3a
Symbol
rps6ka3a Nomenclature History
Previous Names
  • rps6ka3
  • id:ibd1103
  • si:ch211-114c12.12
  • wu:fk86e02
  • zgc:56006
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable ribosomal protein S6 kinase activity. Acts upstream of or within digestive tract development and skin development. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including epidermis; lateral mesoderm; otic vesicle; periderm; and pronephric duct. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Makky et al., 2007
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rps6ka3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Coffin-Lowry syndrome Alliance Coffin-Lowry syndrome 303600
non-syndromic X-linked intellectual disability 19 Alliance Intellectual developmental disorder, X-linked 19 300844
Associated With rps6ka3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR017892 Protein kinase, C-terminal
Domain IPR041905 Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain
Domain IPR041906 Ribosomal S6 kinase, N-terminal catalytic domain
Family IPR016239 Ribosomal protein S6 kinase II
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal Protein kinase, ATP binding site Protein kinase, C-terminal Protein kinase domain Protein kinase-like domain superfamily Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain Ribosomal protein S6 kinase II Ribosomal S6 kinase, N-terminal catalytic domain Serine/threonine-protein kinase, active site
UniProtKB:Q7ZVH8 732
UniProtKB:A0A2R8Q8Y4 685
UniProtKB:A0A0R4ID09 733
UniProtKB:B0R0M9 732
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations