ZFIN ID: ZDB-GENE-030131-998
Gene Name: myosin, heavy chain 9b, non-muscle
Gene Symbol: myh9b    Nomenclature History

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Previous Names: myh91, myh9l1, myhz9 (1), fb55d12, myo2hc9 (1), wu:fb30g06, wu:fb55d12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in actin filament bundle distribution; midbrain-hindbrain boundary morphogenesis; and regulation of cell shape. Predicted to localize to myosin complex. Is expressed in brain; ectoderm; epidermis; pectoral fin; and trunk. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and proteinuria. Orthologous to human MYH9 (myosin heavy chain 9).
Genome Resources: Alliance (1),  Gene:561431 (1),  Ensembl(GRCz11):ENSDARG00000001014 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18627 Point Mutation Unknown Missense, Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33082 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39978 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-myh9b
    1
    CRISPR2-myh9b
    1
    CRISPR3-myh9b
    2
    CRISPR4-myh9b
    2
    MO1-myh9b N/A 1
    DISEASE ASSOCIATED WITH myh9b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 17 Alliance Deafness, autosomal dominant 17 603622
    MYH-9 related disease Alliance Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss 155100
    DISEASE ASSOCIATED WITH myh9b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process actin filament bundle distribution (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myh9b No data available
    MARKER RELATIONSHIPS
    myh9b Contains: [SNP] rs3727673 (1), rs3727674 (1)
    myh9b Encodes: [EST] fb30g06 (1), fb55d12
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_001920063 (1) 5409 nt
    Genomic GenBank:FP325360 (1) 34830 nt
    Select Tool
    Polypeptide UniProtKB:F1QC64 (1) 1749 aa
    Sequence Information (all 17)
    ORTHOLOGY for myh9b ( Chr: 3 )
    CITATIONS (24)