ZFIN ID: ZDB-GENE-030131-9564
Gene Name: leucine-zipper-like transcription regulator 1
Gene Symbol: lztr1    Nomenclature History

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Previous Names: fj87c05, si:dkey-98f17.2 (1), wu:fj87c05, zgc:158250

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to localize to the Golgi apparatus. Human ortholog(s) of this gene implicated in Noonan syndrome 10; Noonan syndrome 2; and neurilemmomatosis. Orthologous to human LZTR1 (leucine zipper like transcription regulator 1).
Genome Resources: Alliance (1),  Gene:792832 (1),  Ensembl(GRCz11):ENSDARG00000015905 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20355 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40365 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lztr1 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH lztr1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    neurilemmomatosis Alliance {Schwannomatosis-2, susceptibility to} 615670
    Noonan syndrome 2 Alliance Noonan syndrome 2 605275
    Noonan syndrome 10 Alliance Noonan syndrome 10 616564
    DISEASE ASSOCIATED WITH lztr1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process biological_process (more)
    Cellular Component Golgi apparatus (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000210 BTB/POZ domain
    Repeat IPR006652 Kelch repeat type 1
    Homologous_superfamily IPR011333 SKP1/BTB/POZ domain superfamily
    Repeat IPR011498 Kelch repeat type 2
    Homologous_superfamily IPR015915 Kelch-type beta propeller
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lztr1-201 (1)    Ensembl 3504
    ncRNA lztr1-002 (1) 529
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lztr1 No data available
    MARKER RELATIONSHIPS
    lztr1 Contained in: [BAC] DKEY-98F17 (1) (order this), DKEYP-98C11 (1)
    lztr1 Encodes: [EST] fj87c05
    [cDNA] MGC:158250 (1), MGC:174591 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001080605 (1) 3522 bp
    Genomic GenBank:CR855305 155542 bp
    Select Tool
    Polypeptide UniProtKB:F1R533 (1) 783 aa
    Sequence Information (all 18)
    ORTHOLOGY for lztr1 ( Chr: 5 )
    CITATIONS (19)