ZFIN ID: ZDB-GENE-030131-95
Gene Name: natriuretic peptide A
Gene Symbol: nppa    Nomenclature History

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Previous Names: anf (1), anp (1), atrial natriuretic factor (1), hm:zeh1304, zeh1304

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have hormone activity and hormone receptor binding activity. Involved in atrioventricular canal development; cardiac jelly development; and cardiac muscle cell proliferation. Predicted to localize to the cytoplasm; extracellular space; and nucleus. Human ortholog(s) of this gene implicated in artery disease (multiple); congestive heart failure; familial atrial fibrillation; and peritonitis. Is expressed in heart rudiment; pericardial region; and skeletal muscle cell. Orthologous to human NPPA (natriuretic peptide A).
Genome Resources: Alliance (1),  Gene:321442 (1),  Ensembl(GRCz11):ENSDARG00000052960 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026619Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25409 Point Mutation Unknown Splice Site ENU
    uq19ks Small Deletion Exon 1 Frameshift TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nppa N/A 1
    MO2-nppa N/A 1
    TALEN1-nppa 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nppa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial atrial fibrillation Alliance Atrial fibrillation, familial, 6 612201
    Atrial standstill 2 615745
    DISEASE ASSOCIATED WITH nppa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process atrioventricular canal development (more)
    Cellular Component extracellular region (more)
    Molecular Function hormone activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000663 Natriuretic peptide
    Conserved_site IPR030480 Natriuretic peptide, conserved site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nppa-201 (1)    Ensembl 1624
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nppa
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(nppa-Xla.Cryaa:Luciferase) nppa Luciferase Danio rerioXenopus laevis 1 2
    Tg(nppa-Xla.Cryaa:YFP) nppa YFP Danio rerioXenopus laevis 1 3
    MARKER RELATIONSHIPS
    nppa Contained in: [BAC] CH211-215J19 (1)
    nppa Encodes: [EST] eu811 (1), eu878 (1), zeh1304
    [cDNA] MGC:152837 (1), MGC:192323 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_198800 (1) 911 bp
    Genomic GenBank:BX323876 (1) 218043 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QVW0 (1) 139 aa
    Sequence Information (all 24)
    ORTHOLOGY for nppa ( Chr: 8 )
    CITATIONS (128)