Gene

plcd1b

ID
ZDB-GENE-030131-9435
Name
phospholipase C, delta 1b
Symbol
plcd1b Nomenclature History
Previous Names
  • DrPLC-delta 1B
  • fj78d10
  • wu:fj78d10
  • zgc:55868
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have phosphatidylinositol phospholipase C activity. Predicted to be involved in inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Is expressed in lens; neuromast; and solid lens vesicle. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (phospholipase C delta 1).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With plcd1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nonsyndromic congenital nail disorder 3 Alliance Nail disorder, nonsyndromic congenital, 3, (leukonychia) 151600
Associated With plcd1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018247 EF-Hand 1, calcium-binding site
Domain IPR000008 C2 domain
Domain IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
Domain IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
Family IPR001192 Phosphoinositide phospholipase C family
Family IPR028391 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Homologous_superfamily IPR035892 C2 domain superfamily
Domain Details Per Protein
Protein Length 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 C2 domain C2 domain superfamily EF-Hand 1, calcium-binding site EF-hand domain pair PH-like domain superfamily Phosphatidylinositol-specific phospholipase C, X domain Phosphoinositide phospholipase C family Phosphoinositide-specific phospholipase C, EF-hand-like domain Phospholipase C, phosphatidylinositol-specific, Y domain PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily Pleckstrin homology domain
UniProtKB:Q7ZU40 749
UniProtKB:F1R8S3 749
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations