ZFIN ID: ZDB-GENE-030131-940
Gene Name: actinin, alpha 4
Gene Symbol: actn4    Nomenclature History

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Previous Names: wu:fb53f05, zgc:63508

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have actin binding activity and calcium ion binding activity. Is expressed in several structures, including digestive system; fin bud; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 1. Orthologous to human ACTN4 (actinin alpha 4).
Genome Resources: Alliance (1),  Gene:322221 (1),  Ensembl(GRCz11):ENSDARG00000099786 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24820 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39517 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH actn4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    focal segmental glomerulosclerosis 1 Alliance Glomerulosclerosis, focal segmental, 1 603278
    DISEASE ASSOCIATED WITH actn4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component cellular_component (more)
    Molecular Function actin binding (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM actn4 No data available
    MARKER RELATIONSHIPS
    actn4 Contains: [SNP] rs3728501 (1), rs3728502 (1), rs3728503 (1)
    actn4 Encodes: [EST] fb53f05
    [cDNA] MGC:63508 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_199586 (1) 4029 nt
    Genomic GenBank:CABZ01115154 (1) 24138 nt
    Polypeptide UniProtKB:A0A2R8QDC7 (1) 923 aa
    Sequence Information (all 35)
    ORTHOLOGY for actn4 ( Chr: 15 )
    CITATIONS (24)