Gene

actn4

ID
ZDB-GENE-030131-940
Name
actinin, alpha 4
Symbol
actn4 Nomenclature History
Previous Names
  • wu:fb53f05
  • zgc:63508
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have actin binding activity and calcium ion binding activity. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 1. Is expressed in several structures, including digestive system; fin bud; nervous system; pericardial region; and pleuroperitoneal region. Orthologous to human ACTN4 (actinin alpha 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With actn4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Glomerulosclerosis, focal segmental, 1 603278
Associated With actn4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018247 EF-Hand 1, calcium-binding site
Conserved_site IPR001589 Actinin-type actin-binding domain, conserved site
Domain IPR001715 Calponin homology domain
Domain IPR002048 EF-hand domain
Domain IPR014837 EF-hand, Ca insensitive
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR036872 CH domain superfamily
Repeat IPR002017 Spectrin repeat
Repeat IPR018159 Spectrin/alpha-actinin
Domain Details Per Protein
Protein Length Actinin-type actin-binding domain, conserved site Calponin homology domain CH domain superfamily EF-Hand 1, calcium-binding site EF-hand, Ca insensitive EF-hand domain EF-hand domain pair Spectrin/alpha-actinin Spectrin repeat
UniProtKB:H9GX78 426
UniProtKB:A0A8M9QBU7 896
UniProtKB:A0A8M9QL95 923
UniProtKB:Q7SYE2 901
UniProtKB:A0A8M9QH34 896
UniProtKB:A0A8M9QH30 923
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations