Gene
stat6
- ID
- ZDB-GENE-030131-9359
- Name
- signal transducer and activator of transcription 6, interleukin-4 induced
- Symbol
- stat6 Nomenclature History
- Previous Names
-
- sb:eu508
- wu:fj66g07
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in innate immune response. Predicted to localize to cytosol and nucleus. Human ortholog(s) of this gene implicated in lipoid nephrosis; prostate carcinoma; and urinary schistosomiasis. Is expressed in digestive system; gill; hematopoietic system; integument; and kidney. Orthologous to human STAT6 (signal transducer and activator of transcription 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu508 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hyper-IgE syndrome 6, autosomal dominant, with recurrent infections | 620532 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000980 | SH2 domain |
| Domain | IPR013799 | STAT transcription factor, protein interaction |
| Domain | IPR013800 | STAT transcription factor, all-alpha domain |
| Domain | IPR013801 | STAT transcription factor, DNA-binding |
| Domain | IPR035857 | STAT6, SH2 domain |
| Domain | IPR048988 | Signal transducer and activator of transcription, linker domain |
| Family | IPR001217 | Transcription factor STAT |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR012345 | STAT transcription factor, DNA-binding, N-terminal |
| Homologous_superfamily | IPR015988 | STAT transcription factor, coiled coil |
| Homologous_superfamily | IPR036535 | STAT transcription factor, N-terminal domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | p53-like transcription factor, DNA-binding domain superfamily | SH2 domain | SH2 domain superfamily | Signal transducer and activator of transcription, linker domain | STAT6, SH2 domain | STAT transcription factor, all-alpha domain | STAT transcription factor, coiled coil | STAT transcription factor, DNA-binding | STAT transcription factor, DNA-binding, N-terminal | STAT transcription factor, N-terminal domain superfamily | STAT transcription factor, protein interaction | Transcription factor STAT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B3DGV1
|
758 |
Interactions and Pathways
No data available
Plasmids
No data available