Gene

rars1

ID
ZDB-GENE-030131-9014
Name
arginyl-tRNA synthetase 1
Symbol
rars1 Nomenclature History
Previous Names
  • rars
  • wu:fa96g09
  • zgc:86730
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have arginine-tRNA ligase activity. Predicted to be involved in arginyl-tRNA aminoacylation. Predicted to localize to cytoplasm. Is expressed in digestive system; immature eye; myotome; nervous system; and somite. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rars1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypomyelinating leukodystrophy 9 Alliance Leukodystrophy, hypomyelinating, 9 616140
Associated With rars1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
Domain IPR005148 Arginyl tRNA synthetase N-terminal domain
Domain IPR008909 DALR anticodon binding
Domain IPR035684 Arginyl-tRNA synthetase, catalytic core domain
Family IPR001278 Arginine-tRNA ligase
Homologous_superfamily IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily IPR036695 Arginyl tRNA synthetase N-terminal domain superfamily
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class Ia, anticodon-binding Aminoacyl-tRNA synthetase, class I, conserved site Arginine-tRNA ligase Arginyl-tRNA synthetase, catalytic core domain Arginyl tRNA synthetase N-terminal domain Arginyl tRNA synthetase N-terminal domain superfamily DALR anticodon binding Rossmann-like alpha/beta/alpha sandwich fold
UniProtKB:F1QLT9 661
UniProtKB:B2GT10 661
UniProtKB:F1QL29 229
UniProtKB:Q5XJ11 661
UniProtKB:E9QJM9 128
UniProtKB:Q7ZVF4 661
UniProtKB:F1QCM2 273
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations