ZFIN ID: ZDB-GENE-030131-9014
Gene Name: arginyl-tRNA synthetase 1
Gene Symbol: rars1    Nomenclature History

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Previous Names: rars, wu:fa96g09, zgc:86730

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have arginine-tRNA ligase activity. Predicted to be involved in arginyl-tRNA aminoacylation. Predicted to localize to cytoplasm. Is expressed in digestive system; immature eye; myotome; nervous system; and somite. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1).
Genome Resources: Alliance (1),  Gene:337070 (1),  Ensembl(GRCz11):ENSDARG00000054530 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014073Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12145 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25165 Point Mutation Unknown Splice Site ENU
    sa43687 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43688 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH rars1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypomyelinating leukodystrophy 9 Alliance Leukodystrophy, hypomyelinating, 9 616140
    DISEASE ASSOCIATED WITH rars1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process arginyl-tRNA aminoacylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function aminoacyl-tRNA ligase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rars-201 (1)    Ensembl 2226
    rars-202 (1)    Ensembl 818
    rars-203 (1)    Ensembl 688
    rars-204 (1)    Ensembl 782
    ncRNA rars-004 (1)    Ensembl 807
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rars1 No data available
    MARKER RELATIONSHIPS
    rars1 Contained in: [BAC] CH211-213N8 (1), DKEYP-23E4 (1)
    rars1 Encodes: [EST] fa96g09
    [cDNA] MGC:56050 (1), MGC:86730 (1), MGC:192806 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200048 (1) 2193 nt
    Genomic GenBank:CT027760 (1) 123310 nt
    Select Tool
    Polypeptide UniProtKB:B2GT10 (1) 661 aa
    Sequence Information (all 26)
    ORTHOLOGY for rars1 ( Chr: 21 )
    CITATIONS (29)