ZFIN ID: ZDB-GENE-030131-899
Gene Name: acyl-CoA dehydrogenase very long chain
Gene Symbol: acadvl    Nomenclature History

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Previous Names: vlcad (1), fb52d04, wu:fb52d04, wu:fc75e01, zgc:64067

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have fatty-acyl-CoA binding activity and very-long-chain-acyl-CoA dehydrogenase activity. Involved in head development. Predicted to localize to mitochondrion. Is expressed in female organism; pectoral fin musculature; and pronephric duct. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain).
Genome Resources: Alliance (1),  Gene:573723 (1),  Ensembl(GRCz11):ENSDARG00000016687 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 2 publications
Directly Submitted Expression Data: 6 figures (6 images) from Thisse et al., 2004 [MGC:64067]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7162137]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2360 Point Mutation Unknown Splice Site ENU
sa20905 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34039 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-acadvl N/A 1
    DISEASE ASSOCIATED WITH acadvl HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    very long chain acyl-CoA dehydrogenase deficiency Alliance VLCAD deficiency 201475
    DISEASE ASSOCIATED WITH acadvl VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process head development (more)
    Cellular Component mitochondrion (more)
    Molecular Function acyl-CoA dehydrogenase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA acadvl-201 (1)    Ensembl 2572
    acadvl-202 (1)    Ensembl 3536
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM acadvl No data available
    MARKER RELATIONSHIPS
    acadvl Contained in: [BAC] DKEY-33C9 (1) (order this)
    acadvl Encodes: [EST] fb52d04, fc75e01 (1), IMAGE:7162137 (1)
    [cDNA] MGC:64067 (1), MGC:174519 (1)
    acadvl Has Artifact: [EST] fo71e09
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212611 (1) 2546 nt
    Genomic GenBank:CR376787 (1) 217684 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A9JT52 (1) 659 aa
    Sequence Information (all 20)
    ORTHOLOGY for acadvl ( Chr: 7 )
    CITATIONS (26)