ZFIN ID: ZDB-GENE-030131-8984
Gene Name: plectin a
Gene Symbol: pleca    Nomenclature History

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Previous Names: plec (1), fa95h11, sb:eu420, si:dkey-151c10.1, wu:fa95h11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have ankyrin binding activity and structural molecule activity. Involved in locomotory behavior and skeletal muscle tissue development. Predicted to colocalize with intermediate filament. Is expressed in epidermis and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2Q; epidermolysis bullosa simplex; epidermolysis bullosa simplex Ogna type; and epidermolysis bullosa simplex with muscular dystrophy. Orthologous to human PLEC (plectin).
Genome Resources: Alliance (1),  Gene:567639 (1),  Ensembl(GRCz11):ENSDARG00000062590 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (9 images) from Thisse et al., 2005 [eu420]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028015Tg Transgenic Insertion Unknown Unknown DNA
sa3001 Point Mutation Unknown Premature Stop ENU
sa7454 Point Mutation Unknown Missense ENU
sa8478 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9648 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10022 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10308 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11832 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14073 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23510 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23511 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36829 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36830 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43271 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43272 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43273 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43274 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • stl261 Small Deletion Exon 3 Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-pleca 1
    MO1-pleca N/A 1
    DISEASE ASSOCIATED WITH pleca HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive limb-girdle muscular dystrophy type 2Q Alliance Muscular dystrophy, limb-girdle, autosomal recessive 17 613723
    epidermolysis bullosa simplex Ogna type Alliance Epidermolysis bullosa simplex, Ogna type 131950
    epidermolysis bullosa simplex with muscular dystrophy Alliance Epidermolysis bullosa simplex with muscular dystrophy 226670
    Epidermolysis bullosa simplex with pyloric atresia 612138
    ?Epidermolysis bullosa simplex with nail dystrophy 616487
    DISEASE ASSOCIATED WITH pleca VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process locomotory behavior (more)
    Cellular Component cytoplasm (more)
    Molecular Function actin binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pleca-201 (1)    Ensembl 720
    pleca-202 (1)    Ensembl 17158
    pleca-203 (1)    Ensembl 15886
    pleca-204 (1)    Ensembl 643
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pleca No data available
    MARKER RELATIONSHIPS
    pleca Contained in: [BAC] CH211-129B17 (1), DKEY-151C10 (1) (order this)
    pleca Contains: [SNP] rs3728974 (1), rs3728975 (1)
    pleca Encodes: [EST] eu420 (1), fa95h11
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001100032 (1) 15886 nt
    Genomic GenBank:BX957242 (1) 167629 nt
    Select Tool
    Polypeptide UniProtKB:A0A286YBE9 (1) 4773 aa
    Sequence Information (all 69)
    ORTHOLOGY for pleca ( Chr: 19 )
    CITATIONS (28)