Gene

ttc8

ID
ZDB-GENE-030131-8846
Name
tetratricopeptide repeat domain 8
Symbol
ttc8 Nomenclature History
Previous Names
  • bbs8 (1)
  • fk26c02
  • wu:fk26c02
  • zgc:136718
Type
protein_coding_gene
Location
Unmapped
Description
Involved in several processes, including Kupffer's vesicle development; animal organ development; and establishment of pigment granule localization. Predicted to localize to BBSome. Used to study ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8).
Genome Resources
Note
None
Expression
All Expression Data
from Tobin et al., 2008
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ttc8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bardet-Biedl syndrome 8 Alliance Bardet-Biedl syndrome 8 615985
retinitis pigmentosa 51 Alliance ?Retinitis pigmentosa 51 613464
Associated With ttc8 Via Experimental Models
Human Disease Fish Conditions Citations
ciliopathy WT + MO3-ttc8 control Tobin et al., 2008
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013026 Tetratricopeptide repeat-containing domain
Family IPR028796 Tetratricopeptide repeat protein 8
Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
Repeat IPR019734 Tetratricopeptide repeat
Domain Details Per Protein
Protein Length Tetratricopeptide-like helical domain superfamily Tetratricopeptide repeat Tetratricopeptide repeat-containing domain Tetratricopeptide repeat protein 8
UniProtKB:Q6P5I7 506
UniProtKB:Q1RLX7 507
Transcripts
Genome Browsers
No data available
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Citations