ZFIN ID: ZDB-GENE-030131-8805
Gene Name: thromboxane A synthase 1 (platelet)
Gene Symbol: tbxas1    Nomenclature History

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Previous Names: wu:fk19d08, zgc:136708

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have thromboxane-A synthase activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to integral component of membrane. Is expressed in heart. Human ortholog(s) of this gene implicated in cerebral infarction and platelet-type bleeding disorder 14. Orthologous to human TBXAS1 (thromboxane A synthase 1).
Genome Resources: Alliance (1),  Gene:792041 (1),  Ensembl(GRCz11):ENSDARG00000002249 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020260Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la020261Tg Transgenic Insertion Unknown Unknown DNA
    la020263Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9271 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36591 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tbxas1 N/A 2
    MO2-tbxas1 N/A 2
    DISEASE ASSOCIATED WITH tbxas1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Ghosal hematodiaphyseal syndrome 231095
    DISEASE ASSOCIATED WITH tbxas1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function heme binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tbxas1-201 (1)    Ensembl 2272
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tbxas1 No data available
    MARKER RELATIONSHIPS
    tbxas1 Contained in: [BAC] CH211-227D19 (1), DKEY-16J24 (1) (order this)
    tbxas1 Encodes: [EST] fk19d08
    [cDNA] MGC:136708 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_205609 (1) 2324 nt
    Genomic GenBank:BX247877 (1) 189537 nt
    Select Tool
    Polypeptide UniProtKB:Q1LUX9 (1) 546 aa
    Sequence Information (all 20)
    ORTHOLOGY for tbxas1 ( Chr: 18 )
    CITATIONS (36)