Gene

psmc1a

ID

ZDB-GENE-030131-8730

Name

proteasome 26S subunit, ATPase 1a

Symbol

psmc1a Nomenclature History

Previous Names

psmc1
wu:fb05d04

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have TBP-class protein binding activity and proteasome-activating ATPase activity. Predicted to be involved in protein catabolic process. Predicted to localize to proteasome regulatory particle, base subcomplex. Orthologous to human PSMC1 (proteasome 26S subunit, ATPase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7145353 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With psmc1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss	Alliance	?Neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss	620071

Associated With psmc1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003960	ATPase, AAA-type, conserved site
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR032501	Proteasomal ATPase OB C-terminal domain
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Family	IPR005937	26S proteasome regulatory subunit P45-like
Family	IPR035244	26S Proteasome regulatory subunit 4
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	26S Proteasome regulatory subunit 4	26S proteasome regulatory subunit P45-like	AAA ATPase, AAA+ lid domain	AAA+ ATPase domain	ATPase, AAA-type, conserved site	ATPase, AAA-type, core	P-loop containing nucleoside triphosphate hydrolase	Proteasomal ATPase OB C-terminal domain
UniProtKB:F8W3U0 InterPro	94
UniProtKB:A0A2R8QG90 InterPro	268
UniProtKB:A0A0R4IFE2 InterPro	483
UniProtKB:Q7ZWD1 InterPro	440
UniProtKB:A8KC30 InterPro	440

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	psmc1a-201 (1) Ensembl	2248 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	psmc1a-202 (1) Ensembl	589 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations