Gene

irs1

ID
ZDB-GENE-030131-872
Name
insulin receptor substrate 1
Symbol
irs1 Nomenclature History
Previous Names
  • fb51f11
  • fd14h02
  • si:dkeyp-51h1.1 (1)
  • wu:fb51f11 (1)
  • wu:fd14h02
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Involved in cellular response to hypoxia. Predicted to localize to cytosol and plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; and type 2 diabetes mellitus. Is expressed in several structures, including digestive system; endocrine system; kidney; nervous system; and pharyngeal arch. Orthologous to human IRS1 (insulin receptor substrate 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Kamei et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irs1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
type 2 diabetes mellitus Alliance {Type 2 diabetes mellitus, susceptibility to} 125853
{Coronary artery disease, susceptibility to}
Associated With irs1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001849 Pleckstrin homology domain
Domain IPR002404 IRS-type PTB domain
Family IPR039011 Insulin receptor substrate
Homologous_superfamily IPR011993 PH-like domain superfamily
Domain Details Per Protein
Protein Length Insulin receptor substrate IRS-type PTB domain PH-like domain superfamily Pleckstrin homology domain
UniProtKB:E7F4P8 1099
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations