ZFIN Gene: rps14

ZFIN ID: ZDB-GENE-030131-8631

ZFIN ID: ZDB-GENE-030131-8631

Gene Name:

ribosomal protein S14

Gene Symbol:

rps14 Nomenclature History

Previous Names:

fa92e08, wu:fa92e08, zgc:73215

Gene Type:

protein_coding_gene

Location:

Chr: 21 Mapping Details/Browsers

Description:

Predicted to have mRNA 5'-UTR binding activity and small ribosomal subunit rRNA binding activity. Involved in chordate embryonic development and erythrocyte maturation. Predicted to localize to cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in chromosome 5q deletion syndrome. Orthologous to human RPS14 (ribosomal protein S14).

Genome Resources:

Alliance (1), Gene:336687 (1), Ensembl(GRCz11):ENSDARG00000036629 (2)

GENE EXPRESSION
All Expression Data:	Fig. 3 from Ear et al., 2016
Wild-type Stages, Structures:	Pharyngula:Prim-5 (24.0h-30.0h) to Hatching:Long-pec (48.0h-60.0h)
	whole organism
High Throughput Expression:	GEO (1) Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa17420	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
zf624	Small Deletion	Exon 2	Premature Stop	CRISPR
zf625	Small Deletion	Exon 2	Inframe Deletion	CRISPR
zf626	Indel	Exon 2	Frameshift, Premature Stop	CRISPR

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-rps14	zf624 zf625 zf626	1
CRISPR2-rps14		1
MO1-rps14	N/A	2

PHENOTYPE

Data:	14 figures from 4 publications
Observed in:	anatomical structure central side anatomical structure right side apoptotic process blood hemoglobin cranium erythrocyte maturation erythroid lineage cell extension eye head heart lens nucleate erythrocyte pigmentation whole organism yolk

DISEASE ASSOCIATED WITH rps14 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
chromosome 5q deletion syndrome	Alliance	Macrocytic anemia, refractory, due to 5q deletion, somatic	153550

DISEASE ASSOCIATED WITH rps14 VIA EXPERIMENTAL MODELS

Human Disease	Fish	Conditions	Citations
chromosome 5q deletion syndrome	rps14^zf624/zf624	standard conditions	Youn et al., 2019

GENE ONTOLOGY

Ontology	GO Term
Biological Process	erythrocyte maturation (more)
Cellular Component	ribosome (more)
Molecular Function	structural constituent of ribosome (more)

GO Terms (all 10)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS No data available

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM rps14 No data available

MARKER RELATIONSHIPS

rps14 Encodes:

[EST] fa92e08
[cDNA] MGC:73215 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_200026 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:CU915785 (1)	83275 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q6PBW3 (1)	151 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 11)

ORTHOLOGY for rps14 ( Chr: 21 )

CITATIONS (29)

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