Gene

herc1

ID

ZDB-GENE-030131-8542

Name

HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

Symbol

herc1 Nomenclature History

Previous Names

wu:fb14f01
zmp:0000000833

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have ubiquitin-protein transferase activity. Orthologous to human HERC1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With herc1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Macrocephaly, dysmorphic facies, and psychomotor retardation	617011

Associated With herc1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR000569	HECT domain
Domain	IPR001870	B30.2/SPRY domain
Domain	IPR003877	SPRY domain
Domain	IPR035768	HERC1, SPRY domain
Family	IPR051625	Diverse Signaling and Regulatory Domain-Containing Protein
Homologous_superfamily	IPR009091	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR035983	HECT, E3 ligase catalytic domain
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Homologous_superfamily	IPR043136	B30.2/SPRY domain superfamily
Repeat	IPR000408	Regulator of chromosome condensation, RCC1
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	B30.2/SPRY domain	B30.2/SPRY domain superfamily	Concanavalin A-like lectin/glucanase domain superfamily	Diverse Signaling and Regulatory Domain-Containing Protein	HECT domain	HECT, E3 ligase catalytic domain	HERC1, SPRY domain	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	Regulator of chromosome condensation, RCC1	SPRY domain	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M3BB18 InterPro	4867
UniProtKB:A0A8M9PPR0 InterPro	4848
UniProtKB:A0A8M3AU96 InterPro	4860
UniProtKB:A0A8M9QHR3 InterPro	4859
UniProtKB:A0A8M3B194 InterPro	4859

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	herc1-201 (1) Ensembl	Ensembl	15,029 nt	Select Tool
mRNA	herc1-202 (1) Ensembl	Ensembl	2,990 nt	Select Tool
mRNA	herc1-203 (1) Ensembl	Ensembl	615 nt	Select Tool
mRNA	herc1-204 (1) Ensembl	Ensembl	1,508 nt	Select Tool
mRNA	herc1-205 (1) Ensembl	Ensembl	667 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations