ZFIN ID: ZDB-GENE-030131-8480
Gene Name: high mobility group box 1b
Gene Symbol: hmgb1b    Nomenclature History

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Previous Names: si:dkey-1m11.1, wu:fa96c07, wu:fb13a05, zgc:165618

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have DNA binding activity, bending and transcription factor binding activity. Predicted to be involved in several processes, including activation of innate immune response; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Predicted to localize to cytoplasm and nuclear chromatin. Is expressed in several structures, including axis; digestive system; intermediate cell mass of mesoderm; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human HMGB1 (high mobility group box 1).
Genome Resources: Alliance (1),  Gene:795095 (1),  Ensembl(GRCz11):ENSDARG00000030479 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la019326Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44825 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hmgb1b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hmgb1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process activation of innate immune response (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 22)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hmgb1b-201 (1)    Ensembl 605
    hmgb1b-202 (1)    Ensembl 1187
    hmgb1b-203 (1)    Ensembl 768
    hmgb1b-205 (1)    Ensembl 841
    ncRNA hmgb1b-003 (1)    Ensembl 291
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hmgb1b No data available
    MARKER RELATIONSHIPS
    hmgb1b Contained in: [BAC] DKEY-1M11 (1) (order this)
    hmgb1b Contains: [SNP] rs3728737 (1), rs3728738 (1)
    hmgb1b Encodes: [EST] fa96c07, fb13a05, fb16g06 (order this)
    [cDNA] MGC:165618 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001099251 (1) 1172 nt
    Genomic GenBank:AL929092 (1) 130947 nt
    Select Tool
    Polypeptide UniProtKB:X1WFI9 (1) 197 aa
    Sequence Information (all 21)
    ORTHOLOGY for hmgb1b ( Chr: 15 )
    CITATIONS (29)