ZFIN ID: ZDB-GENE-030131-8453
Gene Name: ligase III, DNA, ATP-dependent
Gene Symbol: lig3    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: im:7139055, im:7145225, wu:fb12c02, wu:fd10b03, wu:fm79b09, zgc:112973

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have DNA ligase (ATP) activity. Involved in double-strand break repair via alternative nonhomologous end joining. Predicted to localize to DNA ligase III-XRCC1 complex and mitochondrion. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human LIG3 (DNA ligase 3).
Genome Resources: Alliance (1),  Gene:563276 (1),  Ensembl(GRCz11):ENSDARG00000052553 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7139055]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7145225]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7156635]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31480 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44623 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lig3 N/A 1
    DISEASE ASSOCIATED WITH lig3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH lig3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process double-strand break repair via alternative nonhomologous end joining (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lig3 No data available
    MARKER RELATIONSHIPS
    lig3 Contains: [SNP] rs3727919 (1), rs3727920 (1), rs3727921 (1), rs3727922 (1)
    lig3 Encodes: [EST] fb12c02, fd10b03, fm79b09, IMAGE:7139055 (1), IMAGE:7145225 (1), IMAGE:7156635 (1)
    [cDNA] MGC:112973 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001030174 (1)
    Polypeptide UniProtKB:F1QJL4 (1) 1011 aa
    Sequence Information (all 26)
    ORTHOLOGY for lig3 ( Chr: 5 )
    CITATIONS (25)