Gene

glulb

ID
ZDB-GENE-030131-8417
Name
glutamate-ammonia ligase (glutamine synthase) b
Symbol
glulb Nomenclature History
Previous Names
  • fb11d08
  • gso2 (1)
  • hm:zehn1949
  • im:7153900
  • wu:fb11d08
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have glutamate-ammonia ligase activity. Predicted to be involved in glutamine biosynthetic process. Predicted to localize to cytoplasm. Is expressed in several structures, including digestive system; hatching gland; integument; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and temporal lobe epilepsy. Orthologous to human GLUL (glutamate-ammonia ligase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With glulb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Glutamine deficiency, congenital 610015
Associated With glulb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR027302 Glutamine synthetase, N-terminal conserved site
Conserved_site IPR027303 Glutamine synthetase, glycine-rich site
Domain IPR008146 Glutamine synthetase, catalytic domain
Domain IPR008147 Glutamine synthetase, beta-Grasp domain
Homologous_superfamily IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
Homologous_superfamily IPR036651 Glutamine synthetase, N-terminal domain superfamily
Domain Details Per Protein
Protein Length Glutamine synthetase, beta-Grasp domain Glutamine synthetase, catalytic domain Glutamine synthetase, glycine-rich site Glutamine synthetase/guanido kinase, catalytic domain Glutamine synthetase, N-terminal conserved site Glutamine synthetase, N-terminal domain superfamily
UniProtKB:A0A0R4ITW5 193
UniProtKB:Q7M568 242
UniProtKB:Q7ZVF2 372
UniProtKB:A0A2R8QG82 371
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations