ZFIN ID: ZDB-GENE-030131-8246
Gene Name: tau tubulin kinase 2b
Gene Symbol: ttbk2b    Nomenclature History

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Previous Names: fj62e10, sb:eu1102, si:dkey-12h9.11, si:dkey-12h9.14, wu:fj62e10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Predicted to be involved in cilium assembly and peptidyl-serine phosphorylation. Predicted to localize to several cellular components, including ciliary basal body; ciliary transition zone; and nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 11. Orthologous to human TTBK2 (tau tubulin kinase 2).
Genome Resources: Alliance (1),  Gene:569881 (1),  Ensembl(GRCz11):ENSDARG00000043026 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu1102]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ttbk2b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spinocerebellar ataxia type 11 Alliance Spinocerebellar ataxia 11 604432
DISEASE ASSOCIATED WITH ttbk2b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process protein phosphorylation (more)
Cellular Component ciliary basal body (more)
Molecular Function ATP binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ttbk2b-201 (1)    Ensembl 5277
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ttbk2b No data available
MARKER RELATIONSHIPS
ttbk2b Contained in: [BAC] DKEY-12H9 (1) (order this)
ttbk2b Encodes: [EST] eu1102 (1), fj62e10
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001326291 (1)
Genomic GenBank:AL954831 (1) 230844 nt Blast at MegaBLAST
Polypeptide UniProtKB:F1RC23 (1) 928 aa
Sequence Information (all 14)
ORTHOLOGY for ttbk2b ( Chr: 20 )
CITATIONS (20)