Community Action Needed: Please respond to the NIH RFI
Gene

hcn2b

ID
ZDB-GENE-030131-8228
Name
hyperpolarization activated cyclic nucleotide-gated potassium channel 2b
Symbol
hcn2b Nomenclature History
Previous Names
  • hcn2
  • si:dkey-28h18.1
  • wu:fj61d07
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to enable sodium channel activity and voltage-gated potassium channel activity. Predicted to act upstream of or within potassium ion transport; sodium ion transport; and transmembrane transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Orthologous to human HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Trapani et al., 2011
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hcn2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial febrile seizures 2 Alliance Febrile seizures, familial, 2 602477
familial febrile seizures 2 Alliance Generalized epilepsy with febrile seizures plus, type 11 602477
familial febrile seizures 2 Alliance {Epilepsy, idiopathic generalized, susceptibility to, 17} 602477
Associated With hcn2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018488 Cyclic nucleotide-binding, conserved site
Domain IPR000595 Cyclic nucleotide-binding domain
Domain IPR005821 Ion transport domain
Domain IPR013621 Ion transport N-terminal
Family IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
Homologous_superfamily IPR014710 RmlC-like jelly roll fold
Homologous_superfamily IPR018490 Cyclic nucleotide-binding-like
Domain Details Per Protein
Protein Length Cyclic nucleotide-binding, conserved site Cyclic nucleotide-binding domain Cyclic nucleotide-binding-like Ion transport domain Ion transport N-terminal Potassium channel, voltage-dependent, EAG/ELK/ERG RmlC-like jelly roll fold
UniProtKB:A0A2R8RKE8 647
UniProtKB:F1Q9R9 875
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations