ZFIN ID: ZDB-GENE-030131-8227
Gene Name: mitochondrial ribosomal protein L3
Gene Symbol: mrpl3    Nomenclature History

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Previous Names: fj61d01, wu:fj61d01, zgc:66423 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to localize to the mitochondrial large ribosomal subunit. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human MRPL3 (mitochondrial ribosomal protein L3).
Genome Resources: Alliance (1),  Gene:336283 (1),  Ensembl(GRCz11):ENSDARG00000103318 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6909954]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa5920 Point Mutation Unknown Premature Stop ENU
sa36814 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mrpl3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    combined oxidative phosphorylation deficiency 9 Alliance Combined oxidative phosphorylation deficiency 9 614582
    DISEASE ASSOCIATED WITH mrpl3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process translation (more)
    Cellular Component ribosome (more)
    Molecular Function structural constituent of ribosome (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000597 Ribosomal protein L3
    Homologous_superfamily IPR009000 Translation protein, beta-barrel domain superfamily
    Conserved_site IPR019926 Ribosomal protein L3, conserved site
    Family IPR019927 Ribosomal protein L3, bacterial/organelle-type
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mrpl3-201 (1)    Ensembl 1380
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mrpl3 No data available
    MARKER RELATIONSHIPS
    mrpl3 Contained in: [BAC] DKEYP-114F9 (1)
    mrpl3 Encodes: [EST] fj61d01, IMAGE:6909954 (1)
    [cDNA] MGC:66423 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200007 (1) 1305 bp
    Genomic GenBank:CR626877 (1) 173824 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IY00 (1) 345 aa
    Sequence Information (all 16)
    ORTHOLOGY for mrpl3 ( Chr: 19 )
    CITATIONS (23)