ZFIN ID: ZDB-GENE-030131-8207
Gene Name: myosin, light chain kinase a
Gene Symbol: mylka    Nomenclature History

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Previous Names: mylk, fj60a06, mlck1a (1), smMLCK (1), smooth muscle MLCK (1), wu:fj60a06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and protein kinase activity. Involved in blood coagulation and regulation of cell motility. Is expressed in eye and gut. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; asthma; and thoracic aortic aneurysm. Orthologous to human MYLK (myosin light chain kinase).
Genome Resources: Alliance (1),  Gene:569510 (1),  Ensembl(GRCz11):ENSDARG00000034801 (2),  Ensembl(GRCz11):ENSDARG00000090738 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026987Tg Transgenic Insertion Unknown Unknown DNA
sa10145 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10857 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41343 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mylka N/A 1
    MO2-mylka N/A 1
    MO3-mylka N/A 1
    MO4-mylka N/A 1
    MO5-mylka N/A 1
    MO6-mylka N/A 1
    PHENOTYPE
    Data: Fig. 4 from Tournoij et al., 2010
    Observed in:
    DISEASE ASSOCIATED WITH mylka HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    thoracic aortic aneurysm Alliance Aortic aneurysm, familial thoracic 7 613780
    Megacystis-microcolon-intestinal hypoperistalsis syndrome 249210
    DISEASE ASSOCIATED WITH mylka VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of cell motility (more)
    Cellular Component synapse (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ottdart00000045843 (1) 821
    ottdart00000062468 (1) 4630
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mylka No data available
    MARKER RELATIONSHIPS
    mylka Contained in: [BAC] CH73-231O20 (1)
    [Fosmid] CH1073-98I9 (1)
    mylka Encodes: [EST] fj60a06
    [cDNA] MGC:195340 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001105682 (1)
    Genomic GenBank:FP016231 (1) 103256 nt
    Select Tool
    Polypeptide UniProtKB:A8C985 (1) 899 aa
    Sequence Information (all 28)
    ORTHOLOGY for mylka ( Chr: 9 )
    CITATIONS (33)