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Gene

mylka

ID
ZDB-GENE-030131-8207
Name
myosin, light chain kinase a
Symbol
mylka Nomenclature History
Previous Names
  • mylk
  • fj60a06
  • mlck1a (1)
  • smMLCK (1)
  • smooth muscle MLCK (1)
  • wu:fj60a06
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to enable several functions, including ATP binding activity; calmodulin binding activity; and myosin light chain kinase activity. Acts upstream of or within blood coagulation and regulation of cell motility. Predicted to be active in synapse. Is expressed in eye and gut. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; asthma; and thoracic aortic aneurysm. Orthologous to human MYLK (myosin light chain kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Tournoij et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mylka Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
thoracic aortic aneurysm Alliance Aortic aneurysm, familial thoracic 7 613780
Megacystis-microcolon-intestinal hypoperistalsis syndrome 1 249210
Associated With mylka Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR003961 Fibronectin type III
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR015725 Myosin Light Chain Kinase 1, Kinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Myosin Light Chain Kinase 1, Kinase domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:B3DKN5 899
UniProtKB:A8C985 899
UniProtKB:F1R221 899
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations