ZFIN ID: ZDB-GENE-030131-8196
Gene Name: gamma-aminobutyric acid type A receptor subunit beta2a
Gene Symbol: gabrb2a    Nomenclature History

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Previous Names: gabrb2, fj59e04, si:ch211-215g18.1, wu:fj59e04, zgc:136311

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Contributes to GABA-gated chloride ion channel activity. Involved in protein heterotrimerization. Predicted to localize to integral component of plasma membrane; neuron projection; and synapse. Is expressed in nervous system. Human ortholog(s) of this gene implicated in autistic disorder and infantile or early childhood epileptic encephalopathy 2. Orthologous to human GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2).
Genome Resources: Alliance (1),  Gene:336252 (1),  Ensembl(GRCz11):ENSDARG00000079586 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH gabrb2a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
infantile or early childhood epileptic encephalopathy 2 Alliance Epileptic encephalopathy, infantile or early childhood, 2 617829
DISEASE ASSOCIATED WITH gabrb2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process protein heterotrimerization (more)
Cellular Component integral component of membrane (more)
Molecular Function CONTRIBUTES_TO   GABA-gated chloride ion channel activity (more)
GO Terms (all 22)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA gabrb2-201 (1)    Ensembl 3200
gabrb2-202 (1)    Ensembl 907
ncRNA gabrb2-002 (1)    Ensembl 880
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM gabrb2a No data available
MARKER RELATIONSHIPS
gabrb2a Contained in: [BAC] CH211-215G18 (1), DKEY-217K23 (1) (order this)
gabrb2a Encodes: [EST] fj59e04
[cDNA] MGC:136311 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001024387 (1) 3145 nt
Genomic GenBank:BX120008 (1) 221928 nt Blast at MegaBLAST
Polypeptide UniProtKB:A4FUK8 (1) 519 aa
Sequence Information (all 20)
ORTHOLOGY for gabrb2a ( Chr: 14 )
CITATIONS (35)