ZFIN ID: ZDB-GENE-030131-8115
Gene Name: piccolo presynaptic cytomatrix protein a
Gene Symbol: pcloa    Nomenclature History

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Previous Names: si:dkey-108d22.4, wu:fj53e09

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in presynaptic active zone assembly and protein localization to synapse. Predicted to localize to several cellular components, including GABA-ergic synapse; cytoskeleton of presynaptic active zone; and glutamatergic synapse. Is expressed in brain; cerebellum; telencephalon; and torus longitudinalis. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein).
Genome Resources: Alliance (1),  Gene:100148002 (1),  Ensembl(GRCz11):ENSDARG00000063299 (2)
GENE EXPRESSION
All Expression Data: Fig. S4 from Nonet, 2012
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1417 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9380 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11716 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17573 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20227 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20228 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26245 Point Mutation Unknown Premature Stop ENU
    sa26246 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33409 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33410 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33411 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33412 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33413 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40241 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pcloa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    pontocerebellar hypoplasia type 3 Alliance ?Pontocerebellar hypoplasia, type 3 608027
    DISEASE ASSOCIATED WITH pcloa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process presynaptic active zone assembly (more)
    Cellular Component membrane (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pcloa-202 (1)    Ensembl 13853
    pcloa-203 (1)    Ensembl 314
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pcloa No data available
    MARKER RELATIONSHIPS
    pcloa Contained in: [BAC] DKEY-108D22 (1) (order this)
    pcloa Encodes: [EST] fj53e09
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009300233 (1)
    Genomic GenBank:BX469931 (1) 204487 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QC86 (1) 4836 aa
    Sequence Information (all 42)
    ORTHOLOGY for pcloa ( Chr: 4 )
    CITATIONS (22)