ZFIN ID: ZDB-GENE-030131-8032
Gene Name: cullin 2
Gene Symbol: cul2    Nomenclature History

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Previous Names: fj48a06, sb:eu1026, wu:fj48a06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Involved in chordate embryonic development and vasculature development. Predicted to localize to Cul2-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Orthologous to human CUL2 (cullin 2).
Genome Resources: Alliance (1),  Gene:336088 (1),  Ensembl(GRCz11):ENSDARG00000013965 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu1026]
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010745Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la022920Tg Transgenic Insertion Unknown Unknown DNA
    sa24431 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25203 Point Mutation Unknown Premature Stop ENU
    sa44069 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44070 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cul2 N/A 1
    DISEASE ASSOCIATED WITH cul2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cul2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component cullin-RING ubiquitin ligase complex (more)
    Molecular Function ubiquitin protein ligase binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cul2-201 (1)    Ensembl 3010
    cul2-202 (1)    Ensembl 572
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cul2 No data available
    MARKER RELATIONSHIPS
    cul2 Contained in: [BAC] CH211-266D19 (1)
    cul2 Encodes: [EST] eu1026 (1), fj48a06
    cul2 Has Artifact: [cDNA] MGC:92577
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_002666581 (1) 3049 nt
    Genomic GenBank:BX294164 (1) 177516 nt
    Select Tool
    Polypeptide UniProtKB:A0A286Y8D7 (1) 758 aa
    Sequence Information (all 28)
    ORTHOLOGY for cul2 ( Chr: 24 )
    CITATIONS (20)