Gene

supt6h

ID
ZDB-GENE-030131-7949
Name
SPT6 homolog, histone chaperone and transcription elongation factor
Symbol
supt6h Nomenclature History
Previous Names
  • pan
  • Spt6 (1)
  • pandora
  • wu:fj42h11
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have histone binding activity and nucleosome binding activity. Involved in several processes, including negative regulation of histone H3-K27 methylation; otic vesicle development; and somitogenesis. Predicted to localize to transcription elongation factor complex and transcriptionally active chromatin. Orthologous to human SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Keegan et al., 2002
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With supt6h Human Ortholog
No data available
Associated With supt6h Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000980 SH2 domain
Domain IPR003029 S1 domain
Domain IPR006641 YqgF/RNase H-like domain
Domain IPR028083 Spt6 acidic, N-terminal domain
Domain IPR028088 Helix-turn-helix DNA-binding domain of Spt6
Domain IPR028231 Transcription elongation factor Spt6, YqgF domain
Domain IPR032706 Transcription elongation factor Spt6, helix-hairpin-helix motif
Domain IPR035018 Spt6, SH2 domain, C terminus
Domain IPR035019 Spt6, SH2 domain, N terminus
Domain IPR035420 Spt6, SH2 domain
Domain IPR041692 HHH domain 9
Family IPR017072 Transcription elongation factor Spt6
Homologous_superfamily IPR010994 RuvA domain 2-like
Homologous_superfamily IPR012337 Ribonuclease H-like superfamily
Homologous_superfamily IPR012340 Nucleic acid-binding, OB-fold
Homologous_superfamily IPR023319 Tex-like protein, HTH domain superfamily
Homologous_superfamily IPR023323 Tex-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Homologous_superfamily IPR037027 YqgF/RNase H-like domain superfamily
Homologous_superfamily IPR042066 Spt6, Death-like domain
Domain Details Per Protein
Protein Length Helix-turn-helix DNA-binding domain of Spt6 HHH domain 9 Nucleic acid-binding, OB-fold Ribonuclease H-like superfamily RuvA domain 2-like S1 domain SH2 domain SH2 domain superfamily Spt6 acidic, N-terminal domain Spt6, Death-like domain Spt6, SH2 domain Spt6, SH2 domain, C terminus Spt6, SH2 domain, N terminus Tex-like domain superfamily Tex-like protein, HTH domain superfamily Transcription elongation factor Spt6 Transcription elongation factor Spt6, helix-hairpin-helix motif Transcription elongation factor Spt6, YqgF domain YqgF/RNase H-like domain YqgF/RNase H-like domain superfamily
UniProtKB:Q8UVK2 1726
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations