ZFIN ID: ZDB-GENE-030131-7860
Gene Name: caseinolytic mitochondrial matrix peptidase proteolytic subunit
Gene Symbol: clpp    Nomenclature History

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Previous Names: fj37a05, si:dkey-204f11.65 (1), wu:fj37a05 (1), zgc:112333

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have ATP-dependent peptidase activity; ATPase binding activity; and serine-type endopeptidase activity. Predicted to be involved in protein quality control for misfolded or incompletely synthesized proteins. Predicted to localize to endopeptidase Clp complex. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human CLPP (caseinolytic mitochondrial matrix peptidase proteolytic subunit).
Genome Resources: Alliance (1),  Gene:553713 (1),  Ensembl(GRCz11):ENSDARG00000020679 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:112333]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028904Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12373 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH clpp HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Perrault syndrome Alliance Perrault syndrome 3 614129
    DISEASE ASSOCIATED WITH clpp VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component endopeptidase Clp complex (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA clpp-201 (1)    Ensembl 1497
    clpp-202 (1)    Ensembl 694
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM clpp No data available
    MARKER RELATIONSHIPS
    clpp Contained in: [BAC] DKEY-204F11 (order this)
    clpp Encodes: [EST] fj37a05
    [cDNA] MGC:112333 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001020684 (1) 1205 nt
    Genomic GenBank:BX649502 (1) 247387 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q502B9 (1) 266 aa
    Sequence Information (all 13)
    ORTHOLOGY for clpp ( Chr: 3 )
    CITATIONS (28)